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GSK2226649A (compound 2) is a novel activator of satellite cell proliferation and enhanced repair of damaged muscle.

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GSK2226649A Chemical Structure

GSK2226649A Chemical Structure

CAS No. : 1848232-20-1

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GSK2226649A Related Antibodies

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Description

GSK2226649A (compound 2) is a novel activator of satellite cell proliferation and enhanced repair of damaged muscle[1].

In Vitro

GSK2226649A (compound 2) (0.1-10μM) can dose-dependently promote the proliferation of muscle stem cells, and can effectively accelerate the repair of damaged skeletal muscle in an in vivo mouse model of skeletal muscle injury[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK2226649A Related Antibodies
In Vivo

The pharmacokinetic parameters of GSK2226649A(compound 2) in mice

Dose(mg) route Cmax(ng/mL) Tmax(hrs) T1/2(hrs) AUC0-inf(h*ng/mL)
30 oral 1384 0.5 1.6 1720
30 SC 1783 1.0 6.1 12077

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

378.81

Formula

C15H12ClFN6OS
CAS No.
SMILES

O=C(N)C1=C(F)C=CC=C1NC2=NC(NCC3=NC=CS3)=NC=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
References
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GSK2226649A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK2226649A1848232-20-1Otherssatellite cell proliferationmuscle repairInhibitorinhibitorinhibit

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