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Cat. No.: HY-108193

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GW 328267

GW 328267 is an A2A receptor agonist. GW 328267 can be used for research of asthma, COPD and upper respiratory inflammatory disease.

For research use only. We do not sell to patients.

CAS No.: 210237-78-8
Formula: C₂₁H₂₆N₁₀O₄
Molecular Weight:482.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

GW 328267 Chemical Structure

CAS No.: 210237-78-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

GW 328267 is an A2A receptor agonist. GW 328267 can be used for research of asthma, COPD and upper respiratory inflammatory disease^[1].

IC₅₀ & Target^[1]

A2a adenosine receptor

All Adenosine Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	8.8 nM Compound: 1	Potency against cAMP formation in CHO cells expressing recombinant human A2A receptor Potency against cAMP formation in CHO cells expressing recombinant human A2A receptor	[PMID: 15267242]
CHO	EC₅₀	1 μM Compound: 1	Potency against cAMP formation in CHO cells expressing recombinant human A2B receptor Potency against cAMP formation in CHO cells expressing recombinant human A2B receptor	[PMID: 15267242]
CHO	EC₅₀	4.2 nM Compound: GW-328267	Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assay Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assay	[PMID: 20031406]
CHO	EC₅₀	51 nM Compound: GW-328267	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay	[PMID: 20031406]
CHO	EC₅₀	882 nM Compound: GW-328267	Agonist activity at human adenosine A1 receptor expressed in CHO cells by GTPPgammaS binding assay Agonist activity at human adenosine A1 receptor expressed in CHO cells by GTPPgammaS binding assay	[PMID: 20031406]
CHO	IC₅₀	5 nM Compound: 76	Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter	[PMID: 22468757]
PBMC	IC₅₀	1.3 nM Compound: GW-328267	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA	[PMID: 20031406]
PBMC	IC₅₀	2.9 nM Compound: GW-328267	Antiinflammatory activity in rat PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA Antiinflammatory activity in rat PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA	[PMID: 20031406]

Chemical Information

CAS No. 210237-78-8
Molecular Weight 482.50
Formula C₂₁H₂₆N₁₀O₄
SMILES

O[C@H]1[C@@H](O[C@H](C2=NN(N=N2)CC)[C@H]1O)N3C4=NC(N[C@H](CO)CC5=CC=CC=C5)=NC(N)=C4N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Marlene A Jacobson, et al. Adenosine receptor agonists. Expert Opinion on Therapeutic Patents. Volume 12, 2002 - Issue 4. Pages 489-501.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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GW 328267

All Adenosine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GW 328267 Related Classifications

HY-108193 Related Classifications