Gαi2-IN-1
Gαi2-IN-1 is a Gαi2 inhibitor. Gαi2-IN-1 attenuates migration of prostate cancer cells. Gαi2-IN-1 can be used for the research of prostate cancer .
For research use only. We do not sell to patients.
- CAS No.: 2794979-74-9
- Formula: C17H16N2O
- Molecular Weight:264.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Gαi2-IN-1 (Compound 14) (25 μM; 5 h) blocks Docetaxel (HY-B0011)-induced migration of PC3 human AR-negative prostate cancer cells[1].
Gαi2-IN-1 (25 μM; 24 h) blocks Enzalutamide (HY-70002)-, Bicalutamide (HY-14249)-, SAHA (HY-10221)-, and SBI-I-19-induced migration of LNCaP human AR-positive prostate cancer cells[1].
Gαi2-IN-1 (20 μM; 5 h) blocks SAHA-induced migration of PC3 human AR-negative prostate cancer cells[1].
Gαi2-IN-1 (20 μM; 5 h) blocks Docetaxel-induced migration of PC3 human AR-negative prostate cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3 human AR-negative prostate cancer cells
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Concentration:25 μM
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Incubation Time:5 h
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Result:Blocked the stimulatory effect of docetaxel on PC3 cell migration, reducing the migration index to levels comparable to untreated control cells, with statistically significant differences relative to docetaxel-only treated cells.
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Cell Line:LNCaP human AR-positive prostate cancer cells
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Concentration:25 μM
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Incubation Time:24 h
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Result:Blocked the stimulatory effects of enzalutamide, bicalutamide, SAHA, and SBI-I-19 on LNCaP cell migration, reducing migration indices to levels comparable to untreated control cells, with statistically significant differences relative to drug-only treated cells.
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Cell Line:PC3 human AR-negative prostate cancer cells
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Concentration:20 μM
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Incubation Time:5 h
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Result:Blocked the stimulatory effect of SAHA on PC3 cell migration, reducing the migration index to levels comparable to untreated control cells, with statistically significant differences relative to SAHA-only treated cells.\nBlocked the stimulatory effect of docetaxel on PC3 cell migration, reducing the migration index to levels comparable to untreated control cells, with statistically significant differences relative to docetaxel-only treated cells.
Chemical Information
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CAS No. 2794979-74-9
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Molecular Weight 264.32
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Formula C17H16N2O
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SMILES
CN1C2=CC=CC=C2C=C1/C(C)=N/C3=CC=C(O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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