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Cat. No.: HY-151116

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HER2-IN-10

HER2-IN-10 is a psoralen derivative. HER2-IN-10 has anti-breast cancer activity and light-activated cytotoxicity. HER2-IN-10 induces apoptosis.

For research use only. We do not sell to patients.

CAS No.: 1059177-03-5
Formula: C₁₅H₁₃NO₅
Molecular Weight:287.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

HER2-IN-10 Chemical Structure

CAS No.: 1059177-03-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HER2-IN-10 is a psoralen derivative. HER2-IN-10 has anti-breast cancer activity and light-activated cytotoxicity. HER2-IN-10 induces apoptosis^[1].

In Vitro

HER2-IN-10 (50 µM) has phototoxicity against SK-BR-3 cells with the IC₅₀ of 3.05 µM^[1].
HER2-IN-10 (1-50 µM; 48 h) changes the morphology of the SK-BR-3 cells under UVA irradiation and increases the apoptotic index^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

SK-BR-3 cells
Concentration:

1, 2.5, 5, 10, 20 and 50 µM
Incubation Time:

48 hours
Result:

Broken down cells into apoptotic bodies at higher concentrations (10, 20, and 50 µM) and cell shrinkage, plasma membrane blebbing at lower concentrations (1, 2.5, and 5 µM).

Chemical Information

CAS No. 1059177-03-5
Molecular Weight 287.27
Formula C₁₅H₁₃NO₅
SMILES

CCC(NC(C1=C(OC=C1)C(OC)=C2O3)=C2C=CC3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aekrungrueangkit C, et, al. Novel psoralen derivatives as anti-breast cancer agents and their light-activated cytotoxicity against HER2 positive breast cancer cells. Sci Rep. 2022 Aug 5;12(1):13487. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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