Herkinorin
Based on 1 publication(s) in Google Scholar
Herkinorin is a potent and selective agonist of µ opioid receptor with a Ki of 45 nM Herkinorin is widely used for pain research.
For research use only. We do not sell to patients.
- CAS No.: 862073-77-6
- Formula: C28H30O8
- Molecular Weight:494.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Herkinorin
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
1320 nM
Compound: 1c
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Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay
Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay
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[PMID: 18380425] |
| CHO | EC50 |
1320 nM
Compound: 13
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Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells
|
[PMID: 16033256] |
| CHO | EC50 |
500 nM
Compound: 1c
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Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay
Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay
|
[PMID: 18380425] |
| CHO | EC50 |
500 nM
Compound: 13
|
Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor mu1 expressed in CHO cells
Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor mu1 expressed in CHO cells
|
[PMID: 16033256] |
Chemical Information
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CAS No. 862073-77-6
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Molecular Weight 494.53
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Formula C28H30O8
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SMILES
O=C([C@H](C[C@H](OC(C1=CC=CC=C1)=O)C([C@@]23[H])=O)[C@]2(C)CC[C@@]([C@]3(C)C[C@@H](C4=COC=C4)O5)([H])C5=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Herkinorin ameliorates neuronal damage in a pentylenetetrazol-induced epilepsy rat model through altering microglial and astrocytic activation by inhibiting PARP1 and NF-κB. [Abstract]2025 Apr 9:155:114588. PMID: 40209309
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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