Hexahydrosiladifenidol

Hexahydrosiladifenidol (various concentrations; 45 min) binds to the muscarinic receptor on rabbit gastric fundic cells with a K_D of 211 nM^[1].
Hexahydrosiladifenidol (various concentrations; 20 min) inhibits Carbachol (Carbamoylcholine chloride) (HY-B1208)-stimulated aminopyrine accumulation in rabbit gastric fundic cells with a pA₂ of 7.10^[1].
Hexahydrosiladifenidol (various concentrations; 45 min) binds to muscarinic receptors in rabbit submandibular gland with a K_D of 30.6 nM^[1].
Hexahydrosiladifenidol (various concentrations; 45 min) binds to muscarinic receptors in rabbit heart with a K_D of 331 nM^[1].
Hexahydrosiladifenidol (various concentrations; 45 min) binds to M₁ muscarinic receptors in rabbit cerebral cortex with a K_D of 15.7 nM^[1].
Hexahydrosiladifenidol (10^-5 M; 3 min) completely inhibits carbachol-evoked [3H]noradrenaline release in human neuroblastoma SH-SY5Y cells with a K_i of 18 nM, indicating that an M3 muscarinic receptor mediates this release^[2].
Hexahydrosiladifenidol (45 min; 30 min) blocks prejunctional muscarinic receptors in guinea-pig ileum and rat heart with pA₂ values of 8.17 and 6.88, respectively, showing 20 times greater affinity for ileum receptors^[3].
Hexahydrosiladifenidol (45 min) blocks postjunctional muscarinic receptors in guinea-pig ileum with a pA₂ of 8.22^[3].
Hexahydrosiladifenidol (30 min) blocks postjunctional muscarinic receptors in rat left and right atria with pA₂ values of 6.28 and 6.34, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .