Organ selectivity of hexahydrosiladifenidol in blocking pre- and postjunctional muscarinic receptors studied in guinea-pig ileum and rat heart

  • Eur J Pharmacol. 1985 Jul 11;113(1):125-7. doi: 10.1016/0014-2999(85)90352-8.
H Fuder ,  H Kilbinger ,  H Müller
PMID: 3840090 DOI: 10.1016/0014-2999(85)90352-8
Abstract

Pre- and postjunctional pA2 values of the muscarinic antagonist hexahydrosiladifenidol were determined with guinea-pig ileum and rat heart. Hexahydrosiladifenidol did not discriminate between pre- and postjunctional receptors within the same organ but was more potent on the ileum (20-80 times) than on the heart. It is concluded that pre- and postjunctional muscarinic receptors in the heart may differ from those in the ileum.

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