2. MAPK/ERK Pathway
  3. MAP4K
  4. HMC-B17

HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC50 = 11.56 nM). HMC-B17 can be used for the research of cancer.

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HMC-B17

HMC-B17 화학구조

CAS No. : 2935913-83-8

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HMC-B17 Related Antibodies

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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제품 설명

HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC50 = 11.56 nM). HMC-B17 can be used for the research of cancer[1].

Cellular Effect
Cell Line Type Value Description References
BEAS-2B IC50
> 8 μM
Compound: F03; HMC-B17
Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay
[PMID: 38350360]
Jurkat IC50
> 8 μM
Compound: F03; HMC-B17
Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay
[PMID: 38350360]
L02 IC50
> 8 μM
Compound: F03; HMC-B17
Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay
[PMID: 38350360]
MCF-10A IC50
> 8 μM
Compound: F03; HMC-B17
Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay
[PMID: 38350360]
WRL68 IC50
> 8 μM
Compound: F03; HMC-B17
Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay
[PMID: 38350360]
분자량

427.54

화학식

C27H29N3O2
CAS No.
SMILES

COC1=C(C=C(C=C1)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C5CCN(C)CC5)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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HMC-B17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HMC-B172935913-83-8MAP4KMAPK Kinase Kinase KinaseOrallyIL-2Jurkatcanceranti-PD-L1Inhibitorinhibitorinhibit

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상품명:
HMC-B17
Cat. No.:
HY-157838
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