HMC-B17
HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC50 = 11.56 nM). HMC-B17 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2935913-83-8
- Formula: C27H29N3O2
- Molecular Weight:427.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All MAP4K Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BEAS-2B | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
| Jurkat | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
| L02 | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
| MCF-10A | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
| WRL68 | IC50 |
>8 μM
Compound: F03; HMC-B17
|
Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay
Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay
|
[PMID: 38350360] |
Chemical Information
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CAS No. 2935913-83-8
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Molecular Weight 427.54
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Formula C27H29N3O2
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SMILES
COC1=C(C=C(C=C1)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C5CCN(C)CC5)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)