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Cat. No.: HY-163495

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HPK1-IN-44

HPK1-IN-44 (Compound 1) is an inhibitor of HPK1 (IC₅₀=0.1 nM (40 μM ATP)).

For research use only. We do not sell to patients.

CAS No.: 3034319-27-9
Formula: C₂₉H₂₆ClN₅O₂
Molecular Weight:512.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

HPK1-IN-44 Chemical Structure

CAS No.: 3034319-27-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HPK1-IN-44 (Compound 1) is an inhibitor of HPK1 (IC₅₀=0.1 nM (40 μM ATP))^[1].

IC₅₀ & Target^[1]

HPK1

0.1 nM (IC₅₀)

All MAP4K Isoforms :

In Vitro

HPK1-IN-44 cytological activity results are IC₅₀=120.88 nM (pSLP76); EC₅₀=3.67 nM (IL-2 release), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034319-27-9
Molecular Weight 512.00
Formula C₂₉H₂₆ClN₅O₂
SMILES

CC1(C2=CC(N3CCOCC3)=CC=C2NC4=C1C=C(C5=C4C(NC=C5)=O)C6=CN=C7C(Cl)=CC=CN67)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guanglong S et al. HPK1 inhibitor, preparation method therefor, and use thereof.World Intellectual Property Organization, WO2024061345 A1 2024-03-28

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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HPK1-IN-44

All MAP4K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HPK1-IN-44 Related Classifications

HY-163495 Related Classifications