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Cat. No.: HY-189092

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HPPD-IN-14

HPPD-IN-14 is an inhibitor of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase (AtHPPD), with an IC₅₀ of 0.188 μM and a K_i of 0.0077 μM. HPPD-IN-14 forms a stable complex through coordination with the active-site metal ion and multiple non-covalent interactions, thereby inhibiting the growth of target weeds, and exhibits high safety to wheat. HPPD-IN-14 can be used in herbicide-related research.

For research use only. We do not sell to patients.

CAS No.: 2776994-70-6
Formula: C₂₁H₂₁F₃N₂O₅
Molecular Weight:438.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPPD-IN-14 Chemical Structure

CAS No.: 2776994-70-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

AtHPPD

0.188 μM (IC₅₀)

AtHPPD

0.0077 μM (Ki)

In Vitro

HPPD-IN-14 (II-36) inhibits purified Arabidopsis thaliana HPPD with an IC₅₀ of 0.188 μM^[1].
HPPD-IN-14 (II-36) binds to Arabidopsis thaliana HPPD with a binding free energy of -8.778 kcal/mol, via metal chelation, π-π stacking, and hydrophobic interactions with key active site residues^[1].
HPPD-IN-14 (II-36) (0.05-0.09 μM; 30 min) acts as a slow-binding inhibitor of purified Arabidopsis thaliana HPPD, with an inhibition constant (K_i) of 0.0077 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2776994-70-6
Molecular Weight 438.40
Formula C₂₁H₂₁F₃N₂O₅
SMILES

O=C1CCCC(O)=C1C(C2=CC=C(N=C(C(F)(F)F)N(CCOCC)C3=O)C3=C2C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang WJ, et al. Discovery of Triketone-Quinazolinone Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. Journal of agricultural and food chemistry. 2026 Aug 12;74(31):24185-24197.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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