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Cat. No.: HY-189228

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HPPD-IN-15

HPPD-IN-15 is a potent HPPD inhibitor with an IC₅₀ of 52 nM (Arabidopsis thaliana). HPPD-IN-15 inhibits HPPD through chelation of Fe²⁺ by the pyrazole group, π-π stacking, and insertion of the benzyl group into a hydrophobic pocket. HPPD-IN-15 can be used for herbicide development research.

For research use only. We do not sell to patients.

Formula: C₂₁H₁₈ClN₅O₅
Molecular Weight:455.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPPD-IN-15 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

AtHPPD

52 nM (IC₅₀)

In Vitro

HPPD-IN-15 (compound II-19) exhibits extremely potent competitive inhibitory activity against AtHPPD enzyme, with an IC₅₀ of 52 nM^[1].
HPPD-IN-15 (30-120 g a.i./ha; 24 days) exhibits moderate post-emergence herbicidal activity in greenhouse weeds (such as ECHCG, SETVI, DIGSA, etc.)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 455.85
Formula C₂₁H₁₈ClN₅O₅
SMILES

CC1=NN(C(O)=C1C(C2=CC=C3C(N(C(N3C)=O)CC4=CC=CC([N+]([O-])=O)=C4)=C2Cl)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li B, et al. Discovery of Pyrazole-Benzimidazolin-2-One Derivatives as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. Journal of agricultural and food chemistry. 2026 Aug 19;74(32):25119-25128.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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