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Cat. No.: HY-189229

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HPPD-IN-16

HPPD-IN-16 is a potent HPPD inhibitor with an IC₅₀ of 0.146 μM against AtHPPD. HPPD-IN-16 blocks HPPD enzymatic activity, interferes with the biosynthesis of plastoquinone and tocopherol, and causes plant death due to albinism resulting from the lack of photosynthetic pigments. HPPD-IN-16 can be used in herbicide research.

For research use only. We do not sell to patients.

Formula: C₁₇H₁₉ClN₄O₃
Molecular Weight:362.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPPD-IN-16 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

AtHPPD

0.146 μM (IC₅₀)

In Vitro

HPPD-IN-16 (compound I-5) inhibits AtHPPD with an IC₅₀ of 0.146 μM in vitro^[1].
HPPD-IN-16 (30-150 g a.i./ha; 24 days) exhibits excellent broad-spectrum herbicidal activity against various monocotyledonous and dicotyledonous weeds (such as ECHCG, SETVI, DIGSA, AMARE, etc.) and selective safety to peanut^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 362.81
Formula C₁₇H₁₉ClN₄O₃
SMILES

CC1=NN(C(O)=C1C(C2=CC=C3C(N(C(N3C)=O)C(C)C)=C2Cl)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li B, et al. Discovery of Pyrazole-Benzimidazolin-2-One Derivatives as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. Journal of agricultural and food chemistry. 2026 Aug 19;74(32):25119-25128.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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