2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. ICI 89406

ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET.

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ICI 89406 Chemical Structure

ICI 89406 Chemical Structure

CAS No. : 53671-71-9

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Based on 1 publication(s) in Google Scholar

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Description

ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET[1][2].

In Vivo
Animal Model: Rats[2].
Dosage: 0.6, 5 or 50 mg/kg.
Administration: Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis).
Result: Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%.
Molecular Weight

354.40

Formula

C19H22N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=CC=C1)NCCNCC(O)COC2=CC=CC=C2C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥99.0%

COA (245 KB)

Handling Instructions (2659 KB)
References
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ICI 89406 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICI 8940653671-71-9ICI89406ICI-89406Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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HY-15726
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