1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. ICI 89406

ICI 89406 

Cat. No.: HY-15726
Handling Instructions

ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET.

For research use only. We do not sell to patients.

ICI 89406 Chemical Structure

ICI 89406 Chemical Structure

CAS No. : 53671-71-9

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Description

ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET[1][2].

In Vivo
Animal Model: Rats[2].
Dosage: 0.6, 5 or 50 mg/kg.
Administration: Orally (5 or 50 mg/kg), i.p. (5 mg/kg), i.v. 0.6 (0.6 mg/kg) (Pharmacokinetic Analysis).
Result: Following oral administration, the dose of 5 mg/kg urinary and faecal excretion accounted for 5.8 + 0.7% and 96.4 + 2.1%. The dose of 50 mg/kg urinary and faecal excretion accounted for 14.0 + 4.0% and 78.4 + 2.4%. The proportions of unchanged drug and metabolites in urine were independent of the dose. The unchanged drug accounted for 81.6% of the faecal components after a dose of 5 mg/kg but this was reduced to 47.8%.
Molecular Weight

354.40

Formula

C₁₉H₂₂N₄O₃

CAS No.

53671-71-9

SMILES

O=C(NC1=CC=CC=C1)NCCNCC(O)COC2=CC=CC=C2C#N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ICI 89406ICI89406ICI-89406Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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