Cat. No.: HY-111550

Bragsin2

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC₅₀ of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells.

For research use only. We do not sell to patients.

Purity: 99.85%
CAS No.: 342795-08-8
Formula: C₁₁H₆F₃NO₅
Molecular Weight:289.16

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Bragsin2 Chemical Structure

CAS No.: 342795-08-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 3 μM (BRAG2)^[1]

All Ras Isoforms :

In Vitro

Bragsin2 (50 μM) inhibits Arf GTPase activation in HeLa cells^[1].
Bragsin2 (50 μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 342795-08-8
Appearance Solid
Molecular Weight 289.16
Formula C₁₁H₆F₃NO₅
Color Off-white to light yellow
SMILES

O=C1C=C(C(F)(F)F)OC2=CC=C(OC)C([N+]([O-])=O)=C21
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

J Biol Chem

The small molecule inhibitor NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins. [Abstract]

2023 Mar;299(3):102992. PMID: 36758799

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (345.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4583 mL

17.2915 mL

34.5829 mL

5 mM

0.6917 mL

3.4583 mL

6.9166 mL

10 mM

0.3458 mL

1.7291 mL

3.4583 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4583 mL	17.2915 mL	34.5829 mL	86.4573 mL
	5 mM	0.6917 mL	3.4583 mL	6.9166 mL	17.2915 mL
	10 mM	0.3458 mL	1.7291 mL	3.4583 mL	8.6457 mL
	15 mM	0.2306 mL	1.1528 mL	2.3055 mL	5.7638 mL
	20 mM	0.1729 mL	0.8646 mL	1.7291 mL	4.3229 mL
	25 mM	0.1383 mL	0.6917 mL	1.3833 mL	3.4583 mL
	30 mM	0.1153 mL	0.5764 mL	1.1528 mL	2.8819 mL
	40 mM	0.0865 mL	0.4323 mL	0.8646 mL	2.1614 mL
	50 mM	0.0692 mL	0.3458 mL	0.6917 mL	1.7291 mL
	60 mM	0.0576 mL	0.2882 mL	0.5764 mL	1.4410 mL
	80 mM	0.0432 mL	0.2161 mL	0.4323 mL	1.0807 mL
	100 mM	0.0346 mL	0.1729 mL	0.3458 mL	0.8646 mL

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Publications Citing Use of MedChemExpress (MCE) Bragsin2

All Ras Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Bragsin2 Related Classifications

HY-111550 Related Classifications