II-B08
Based on 1 Customer Validation
II-B08 is a reversible and noncompetitive SHP2 inhibitor (IC50: 5.5 μM, 15.7, 14.3 μM for SHP2, SHP1, PTP1B). II-B08 can be used for cancer research.
For research use only. We do not sell to patients.
- Purity: 95.00%
- CAS No.: 1143579-78-5
- Formula: C33H27N5O4
- Molecular Weight:557.60
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1143579-78-5
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Appearance Solid
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Molecular Weight 557.60
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Formula C33H27N5O4
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Color Light brown to brown
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SMILES
O=C(C1=CC2=C(N(C)C(C3=CC=CC=C3)=C2C4=CN(CCC(NC5=CC=C(C6=CC=CC=C6)C=C5)=O)N=N4)C=C1O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Zeng LF, et al. Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem. 2014 Aug 14;57(15):6594-609. [Content Brief]
[2]. Zhang X, et al. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J Med Chem. 2010 Mar 25;53(6):2482-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
II-B08 Related Classifications
HY-120901 Related Classifications
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