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Cat. No.: HY-201628

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IMB-881

Name: IMB-881
Brand: MedChemExpress
SKU: HY-201628
Price: 135.00 USD
Availability: InStock
Rating: 5 (1 reviews)

IMB-881 is an antibacterial agent. IMB-881 binds to LptA to inhibit the interaction between LptA and LptC. IMB-881 shows potent antibacterial activity against Gram-negative bacteria.

For research use only. We do not sell to patients.

Purity: 90%
CAS No.: 501017-82-9
Formula: C₁₉H₁₇ClN₂O
Molecular Weight:324.80

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

IMB-881 Chemical Structure

CAS No.: 501017-82-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IMB-881 is an antibacterial agent. IMB-881 binds to LptA to inhibit the interaction between LptA and LptC. IMB-881 shows potent antibacterial activity against Gram-negative bacteria^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	22.7 μM Compound: 3	Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay	[PMID: 36793433]

Chemical Information

CAS No. 501017-82-9
Appearance Solid
Molecular Weight 324.80
Formula C₁₉H₁₇ClN₂O
Color White to off-white
SMILES

ClC(C1=CC=CN=C12)=CC3=C2OCN(CCC4=CC=CC=C4)C3
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu C, et al. Synthesis, biological evaluation and validation of IMB-881 derivatives as anti-Gram-negative bacterial agents. Bioorg Med Chem. 2025 Mar 1;119:118066. [Content Brief]

[2]. Zhang X, et al. Identification of an anti-Gram-negative bacteria agent disrupting the interaction between lipopolysaccharide transporters LptA and LptC. Int J Antimicrob Agents. 2019 Apr;53(4):442-448. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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