IMB-881
IMB-881 is an antibacterial agent. IMB-881 binds to LptA to inhibit the interaction between LptA and LptC. IMB-881 shows potent antibacterial activity against Gram-negative bacteria.
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- Reinheit : 90%
- CAS. Nr.: 501017-82-9
- Formel: C19H17ClN2O
- Molecular Weight:324.80
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
22.7 μM
Compound: 3
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Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition by XTT assay
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[PMID: 36793433] |
Chemical Information
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CAS. Nr. 501017-82-9
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Appearance Solid
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Molecular Weight 324.80
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Formel C19H17ClN2O
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Color White to off-white
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SMILES
ClC(C1=CC=CN=C12)=CC3=C2OCN(CCC4=CC=CC=C4)C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Liu C, et al. Synthesis, biological evaluation and validation of IMB-881 derivatives as anti-Gram-negative bacterial agents. Bioorg Med Chem. 2025 Mar 1;119:118066. [Content Brief]
[2]. Zhang X, et al. Identification of an anti-Gram-negative bacteria agent disrupting the interaction between lipopolysaccharide transporters LptA and LptC. Int J Antimicrob Agents. 2019 Apr;53(4):442-448. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IMB-881 Related Classifications
HY-201628 Related Classifications
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