Histamine Receptor Control

1-Methyl-4-imidazoleacetic acid hydrochloride is a stable metabolite of Histamine (HY-B1204) that is produced by the oxidation of the primary metabolite, N-methylhistamine.

BP 2-94 (BP 2.94) is an orally active and highly selective prodrug targeting the histamine H3 receptor. BP 2-94 exerts anti-inflammatory, analgesic and antinociceptive effects by inhibiting histamine release and modulating neurogenic inflammation. BP 2-94 is promising for research of asthma, migraines, and inflammatory pain-related disorders.

Cetirizine N-oxide dihydrochloride is an oxidative degradation product of the histamine H1 receptor antagonist Cetirizine (HY-17042).

Meclizine N-oxide is a metabolite of the histamine H1 receptor antagonist Meclizine (HY-B0349A).

Desmethyl mirtazapine (Normirtazapine) hydrochloride is a metabolite of Mirtazapine (HY-B0352). Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent.

Sopromidine is a potent and stereoselective isomer of the achiral H2-agonist Impromidine (HY-116777).

Cetirizine N-oxide is an oxidative degradation product of the histamine H1 receptor antagonist Cetirizine (HY-17042).

Promethazine sulfoxide is a metabolite of the histamine H1 receptor antagonist Promethazine (HY-B1296). It is formed from promethazine by the cytochrome P450 (CYP) isoform CYP2D6.