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Cat. No.: HY-W170126

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CB6513745

CB6513745 is a MelF flavin-dependent oxidoreductase inhibitor with a K_i of 18 μM against Mycobacterium marinum MelF. CB6513745 inhibits the activity of MelF flavin-dependent oxidoreductase via hydrophobic interactions with the binding pocket of the protein. CB6513745 is applicable to research related to tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 380449-90-1
Formula: C₂₀H₂₂N₂O₂
Molecular Weight:322.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CB6513745 Chemical Structure

CAS No.: 380449-90-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

CB6513745 noncompetitively inhibits the flavin oxidoreductase activity of purified Mycobacterium marinum MelF protein with a K_i of 18 μM, without causing protein denaturation or aggregation^[1].
CB6513745 exhibits bactericidal activity against Mycobacterium marinum strain M with an MIC of 19.39 μM and MBC of 38.77 μM, and against Mycobacterium tuberculosis H37Rv with an MIC of 38.77 μM and MBC of 38.77 μM; it also acts synergistically with INH against M. marinum^[1].
CB6513745 (19.39-96.95 μM; 20 h) is non-cytotoxic to HeLa cells at concentrations up to 5X its MIC against Mycobacterium marinum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 380449-90-1
Molecular Weight 322.41
Formula C₂₀H₂₂N₂O₂
SMILES

OCC1=CN(N=C1C=2C=CC(OCC(C)C)=CC2)C=3C=CC=CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dharra R, et al. Rational design of drug-like compounds targeting Mycobacterium marinum MelF protein. PLoS One. 2017;12(9):e0183060. Published 2017 Sep 5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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