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Cat. No.: HY-P1396

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GRK2i

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

GRK2i is a Gβγ-inhibitory peptide that selectively prevents Gβγ-mediated signaling. GRK2i corresponds to the Gβγ-binding domain of GRK2 (G-protein-coupled receptor kinase 2).

For research use only. We do not sell to patients.

CAS No.: 148505-03-7
Formula: C₁₅₃H₂₅₆N₅₀O₄₁S
Molecular Weight:3484.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GRK2i Chemical Structure

CAS No.: 148505-03-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
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Biological Activity

Description

GRK2i is a Gβγ-inhibitory peptide that selectively prevents Gβγ-mediated signaling. GRK2i corresponds to the Gβγ-binding domain of GRK2 (G-protein-coupled receptor kinase 2)^[1].

IC₅₀ & Target

GRK2

In Vitro

GRK2i (5 μM) inhibits neurite formation, disrupts microtubules, and induces neurite damag in PC12 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 148505-03-7
Molecular Weight 3484.08
Formula C₁₅₃H₂₅₆N₅₀O₄₁S
Sequence Shortening

WKKELRDAYREAQQLVQRVPKMKNKPRS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

2025 March 13.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jorge A Sierra-Fonseca, et al. Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. BMC Neurosci. 2014 Dec 31;15:132. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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GRK2i

Publications Citing Use of MedChemExpress (MCE) GRK2i