PT150
Based on 1 Customer Validation
PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinson’s disease.
For research use only. We do not sell to patients.
- Purity: 96.70%
- CAS No.: 189035-07-2
- Formula: C28H30O4
- Molecular Weight:430.54
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
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Clinical Compound Library
HY-L026
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Drug Repurposing Compound Library
HY-L035
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Orally Active Compound Library
HY-L061
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Neuroprotective Compound Library
HY-L070
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Antidepressant Compound Library
HY-L108
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Nuclear Receptor Compound Library
HY-L126
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HY-L026P
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6 mice (2.5 mg/kg/day rotenone by intraperitoneal injection for 14 days)[2]
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Dosage:30, 100 mg/kg
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Administration:P.o.; daily for 14 days
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Result:Reduced the loss of dopaminergic neuron (DAn) cell bodies in the substantia nigra (SN), but not the striatum, and prohibited intra-neuronal accumulation of α-synuclein (α-syn).
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 189035-07-2
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Appearance Solid
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Molecular Weight 430.54
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Formula C28H30O4
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Color White to light yellow
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SMILES
O[C@]1(C#CC)[C@]2(C)[C@H]([C@H](CC3)C([C@@H](C4=CC5=C(C=C4)OCO5)C2)=C6C3=CC(CC6)=O)CC1
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Synonyms
ORG-34517
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Morice C, et al. A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers. Sci Rep. 2021 May 10;11(1):9876. [Content Brief]
[2]. Latham AS, et al. Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589261. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PT150 Related Classifications
HY-125558 Related Classifications
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