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Cat. No.: HY-122724

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IQDMA

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

IQDMA is an anti-tumor compound. IQDMA can induce apoptosis in tumor cells, such as K562 cells.

For research use only. We do not sell to patients.

CAS No.: 401463-02-3
Formula: C₁₉H₂₀N₄
Molecular Weight:304.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

IQDMA Chemical Structure

CAS No.: 401463-02-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IQDMA is an anti-tumor compound. IQDMA can induce apoptosis in tumor cells, such as K562 cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.83 μM Compound: 12a	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 20171108]
Detroit 551	IC₅₀	2.21 μM Compound: 12a	Antiproliferative activity against human Detroit 551 cells by MTT assay Antiproliferative activity against human Detroit 551 cells by MTT assay	[PMID: 20171108]
HeLa	IC₅₀	0.61 μM Compound: 12a	Antiproliferative activity against human HeLa cells by MTT assay Antiproliferative activity against human HeLa cells by MTT assay	[PMID: 20171108]
L6	IC₅₀	626.8 nM Compound: 14k	Cytotoxicity against rat L6 cells assessed as cell growth inhibition Cytotoxicity against rat L6 cells assessed as cell growth inhibition	[PMID: 34710743]
PC-3	IC₅₀	5.79 μM Compound: 12a	Antiproliferative activity against human PC3 cells by MTT assay Antiproliferative activity against human PC3 cells by MTT assay	[PMID: 20171108]

Chemical Information

CAS No. 401463-02-3
Molecular Weight 304.39
Formula C₁₉H₂₀N₄
SMILES

CN(C)CCNC1=NC2=CC=CC=C2C3=C1C4=C(N3)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Sci Adv

JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells. [Abstract]

2024 Mar 22;10(12):eadl0368. PMID: 38507500

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lin, et al. "Induction of G2/M phase arrest and apoptosis by a novel indoloquinoline derivative, IQDMA, in K562 cells." Drug development research 67.9 (2006): 743-751.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Publications (1)
Purity & Documentation
References

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IQDMA

Publications Citing Use of MedChemExpress (MCE) IQDMA