Newborn Screening

β-aminomethyl-L-alanine-¹³C,¹⁵N₂ (dihydrochloride) is the ¹³C and ¹⁵N labeled β-aminomethyl-L-alanine.

Fmoc-Met-OH-¹⁵N is the ¹⁵N labeled Fmoc-Met-OH.

3-Chlorotyrosine-¹³C₉,¹⁵N (hydrochloride) is the ¹³C and ¹⁵N labeled 3-Chlorotyrosine.

Fmoc-Ala-OH-¹⁵N is the ¹⁵N labeled Fmoc-Ala-OH.

L-Asparagine-4-¹³C monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443).L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.

(±)-N-(2-Methylbutyryl)glycine-2,2-d₂ is the deuterium labeled (±)-N-(2-Methylbutyryl)glycine-2,2.

2-Methylbutyrylglycine-d₉ is the deuterium labeled 2-Methylbutyrylglycine.

N-Isovaleroylglycine-d₂ is the deuterium labeled N-Isovaleroylglycine (HY-W015464). N-Isovaleroylglycine is a peptidylglycine α-amidating monooxygenase (PAM) inhibitor with a K_i value of 2.0 mM against human hsPAM. N-Isovaleroylglycine undergoes oxidative cleavage by purified rat PAM to produce fatty acid amide and glyoxylic acid. N-Isovaleroylglycine exerts competitive inhibition by binding to hsPAM, blocking the amidation of dansyl-Tyr-Val-Gly. N-Isovaleroylglycine exhibits lowered urinary abundance in MRSA-infected mice, which qualifies it as a non-invasive biomarker. N-Isovaleroylglycine can be used in studies related to Staphylococcus aureus pneumonia and diabetic foot.

N-Propionyl-d₅-glycine is the deuterium labeled N-Propionyl-glycine.

L-Alanine-2-¹³C,¹⁵Nis the ¹³C-labeled and ¹⁵N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.

N-Butyrylglycine-d₇ is the deuterium labeled N-Butyrylglycine.

DL-Proline-2-d₁ is the deuterated-labeled DL-Proline (HY-W012908). DL-Proline is a racemic mixture of D-Proline and L-Proline, belonging to cyclic imino acids with a five-membered ring structure. DL-Proline serves as a key structural unit in peptide synthesis. DL-Proline stabilizes β-turn conformations and affects the secondary structure of peptide segments. DL-Proline exhibits biological activities such as regulating peptide segment conformations and enhancing cyclic peptide stability. DL-Proline can be used in research on diseases related to peptide structure and function, including cancer and bacterial infections.

Fmoc-L-Lys (Boc)-OH-¹³C₆,¹⁵N₂ is a ¹⁵N-labeled and ¹³C-labled Fmoc-L-Lys (Boc)-OH (HY-79128). Fmoc-L-Lys (Boc)-OH is a lysine derivative.

Fmoc-Arg(Pbf)-OH-¹³C₆ is the ¹³C labeled Fmoc-Arg(Pbf)-OH. Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis).

Fmoc-Asp(OtBu)-OH-¹³C₄,¹⁵N is the ¹³C and ¹⁵N labeled Fmoc-Asp(OtBu)-OH. Fmoc-Asp(OtBu)-OH (4-tert-Butyl N-(fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp(OtBu)-OH can be used for peptide synthesis.

Fmoc-His(Trt)-OH-¹⁵N₃ is the ¹⁵N labeled Fmoc-His(Trt)-OH (HY-W010712). Fmoc-His (Trt)-OH is a histidine derivative. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation.

Fmoc-Ile-OH-¹³C₆,¹⁵N is the ¹³C and ¹⁵N labeled Fmoc-Ile-OH. Fmoc-Ile-OH is an isoleucine derivative.

Fmoc-Glu(OtBu)-OH-¹⁵N is a ¹⁵N-labeled Fmoc-Glu(OtBu)-OH.

Fmoc-Pro-OH-¹³C₅,¹⁵N is a ¹⁵N-labeled and ¹³C-labled Fmoc-Pro-OH (HY-W013780). Fmoc-Pro-OH is a proline derivative.

(Rac)-2-Aminobutyric acid-d₃ is the deuterium labeled (Rac)-2-Aminobutyric acid.