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Cat. No.: HY-149278

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Complement C1s-IN-1

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Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC₅₀ value of 36 nM.

For research use only. We do not sell to patients.

Purity: 97.77%
CAS No.: 3033831-40-9
Formula: C₂₂H₂₀F₂N₆O
Molecular Weight:422.43

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Complement C1s-IN-1 Chemical Structure

CAS No.: 3033831-40-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC₅₀ value of 36 nM^[1].

IC₅₀ & Target

IC₅₀: 36 nM (C1s)^[1]

In Vivo

Complement C1s-IN-1 (compound (R)-8) (10, 30, 100 mg/kg; p.o.) inhibits MAC formation induced by human serum and shows plasma exposure after oral administration in a dose-dependent manner^[1].
Pharmacokinetic Parameters of Complement C1s-IN-1 in Male C57BL/6J mice^[1].

Dosage (mg/kg)	C_max (ng/mL)	T_max (h)	AUC_(0-24h) (h* ng/mL)	MRT (h)
10	1032.5±173.0	1.67±0.58	6017.8±390.4	4.31±0.23
30	2583.3±267.1	2.67±1.15	21928.6±1428.2	5.02±0.18
100	8895.9±1516.8	4.00±0.00	13934.1±36760.1	7.66±0.99

Male C57BL/6J mice, 10, 30, 100 mg/kg; p.o.^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6J mice^[1]
Dosage:

10, 30, 100 mg/kg
Administration:

P.o.
Result:

Significantly inhibited MAC formation induced by human serum in a dose-dependent manner.

Chemical Information

CAS No. 3033831-40-9
Appearance Solid
Molecular Weight 422.43
Formula C₂₂H₂₀F₂N₆O
Color Off-white to light yellow
SMILES

NC1=C(C(F)=CC(N2C[C@H](C3=NOC(C)=C3)N(C4=CC(F)=CC=C4)CC2)=C5)C5=CN=N1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ikeda Z, et al. Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway. J Med Chem. 2023 Apr 25. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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