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Cat. No.: HY-112958

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Fomivirsen

(Synonyms: ISIS-2922)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Fomivirsen (ISIS-2922) is an antisense phosphorothioate oligonucleotide. Fomivirsen is an antiviral reagent used in research on cytomegalovirus (CMV) retinitis. Fomivirsen binds to and degrades the mRNA of CMV immediate-early 2 protein, thereby inhibiting viral proliferation. Fomivirsen can be used in research related to cytomegalovirus retinitis and cytomegalovirus diseases.

For research use only. We do not sell to patients.

Purity: 99.47%
CAS No.: 144245-52-3
Formula: C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀
Molecular Weight:6682.40

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Fomivirsen Chemical Structure

CAS No.: 144245-52-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Fomivirsen (0.1-10 μM; overnight) potently inhibits the replication of the HCMV strain AD169 in NHDF cells, with a mean EC₅₀ of 0.37 μM^[1].
Fomivirsen (1.2-10 μM; overnight) reduces the total infectious HCMV titer by 2 log units at a concentration of 2.2 μM, and reduces the intracellular titer by >3 log units at 10 μM, in NHDF cells^[1].
Fomivirsen (0.1-1 μM; overnight pre-treatment) inhibits HCMV plaque formation in NHDF cells; for the AD169 strain, its IC₇₀ is 0.1 μM, and for the Towne strain, its EC₅₀ is 0.3 μM^[1].
Fomivirsen (0.25-8 μM; 15-24 h) reduces the protein expression of HCMV IE1 and IE2 in NHDF cells in a dose-dependent manner^[1].
Fomivirsen inhibits HCMV with an EC₅₀ of 0.1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

NHDF cells infected with HCMV (MOI 0.5 PFU per cell)
Concentration:

0.25-8 μM
Incubation Time:

Overnight
Result:

Reduced steady-state levels of both 72 kDa and 86 kDa IE polypeptides in a dose-dependent manner.
Significantly reduced polypeptide levels at 0.5 μM.

Immunofluorescence^[1]

Cell Line:

NHDF cells infected with HCMV (MOI 3 PFU per cell)
Concentration:

1 μM
Incubation Time:

15-20 h
Result:

Reduced the proportion of HCMV-infected cells exhibiting nuclear immunofluorescence to <10% (from >70% in untreated cells).
Reduced the intensity of fluorescence in positive cells.

Parmacokinetics

Species	Dose	Route	T_1/2
Rabbit^[2]	66 μg	i.v.t	62 h

Chemical Information

CAS No. 144245-52-3
Appearance Solid
Molecular Weight 6682.40
Formula C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀
Color White to off-white
SMILES

[Fomivirsen]
Synonyms

ISIS-2922
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (2)

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J Mass Spectrom

Characterisation of Antisense Oligonucleotides by Ion-Pair Reversed-Phase UHPLC-HRMS: Method development using Design of Experiments. [Abstract]

2026 Apr;61(4):e70049. PMID: 41856548
bioRxiv

2025 Nov 10.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (289 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2242 KB)

References

[1]. Azad RF, et al. Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region. Antimicrob Agents Chemother. 1993;37(9):1945-1954. [Content Brief]

[2]. Leeds JM, et al. Pharmacokinetics of a potential human cytomegalovirus therapeutic, a phosphorothioate oligonucleotide, after intravitreal injection in the rabbit. Drug Metab Dispos. 1997 Aug;25(8):921-6. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (2)
Purity & Documentation
References

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Fomivirsen

Publications Citing Use of MedChemExpress (MCE) Fomivirsen