ETV6 - ETS variant transcription factor 6 Gene

Also Known as TEL; THC5; TEL/ABL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2120

About ETV6

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:11,649,674-11,895,377 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues, 28 paralogues and is associated with 132 phenotypes. Ubiquitous expression in appendix (RPKM 7.0), bone marrow (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and Other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]

ETV6 Products (7)

mRNA	Protein	Name
NM_001413913.1	NP_001400842.1	transcription factor ETV6 isoform 2
NM_001413914.1	NP_001400843.1	transcription factor ETV6 isoform 3
NM_001413915.1	NP_001400844.1	transcription factor ETV6 isoform 4
NM_001413916.1	NP_001400845.1	transcription factor ETV6 isoform 5
NM_001413917.1	NP_001400846.1	transcription factor ETV6 isoform 6
NM_001413918.1	NP_001400847.1	transcription factor ETV6 isoform 7
NM_001987.5	NP_001978.1	transcription factor ETV6 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10514502	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9018121	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12590135	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	12588862	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	25581430	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10514502	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10514502	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETV6 Protein Structure

SAM_PNT

Ets

0
100
200
300
400
452 a.a.

Protein Preferred Names	Protein Names
transcription factor ETV6	ETS-related protein Tel1

ETV6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ETV6	P41212	AP1M1	Homo sapiens	Q9BXS5	Y2H Array	25416956
Intra	ETV6	P41212	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
Intra	ETV6	P41212	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	ETV6	P41212	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	25416956
Intra	ETV6	P41212	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	ETV6	P41212	HDAC9	Homo sapiens	Q9UKV0-3	Anti Bait CoIP	12590135
Intra	ETV6	P41212	HDAC9	Homo sapiens	Q9UKV0-3	Pull Down	12590135

Cross: Cross-species interaction Intra: Intraspecies interaction

ETV6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83171	ETV6 Antibody (YA2916)	WB, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Thrombocytopenia 5	THC5 Thrombocytopenia 5 With Increased Susceptibility To Malignancy Thrombocytopenia, Autosomal Dominant, 5 Thrombocytopenia 5 With Increased Malignancy
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Primary Hypereosinophilic Syndrome	Clonal Hypereosinophilic Syndrome Hes-M Hes-N Neoplastic Hypereosinophilic Syndrome Primary Hes Hm Syndrome
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Congenital Mesoblastic Nephroma	Mesoblastic Nephroma Nephroma, Mesoblastic
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Platelet Disorder, Familial, With Associated Myeloid Malignancy	FPDMM Fpd/Aml Familial Platelet Disorder With Associated Myeloid Malignancy Platelet Disorder, Aspirin-Like Fps/Aml Familial Platelet Disorder With Predisposition To Acute Myelogenous Leukemia Familial Platelet Disorder With Predisposition To Myeloid Malignancy Familial Platelet Disorder With Propensity To Acute Myeloid Leukemia Familial Thrombocytopenia With Propensity To Acute Myelogenous Leukemia Thrombocytopenia, Familial, With Propensity To Acute Myelogenous Leukemia Asprin-Like Platelet Disorder Fpd/Aml Syndrome Fps/Aml Syndrome Familial Platelet Syndrome With Predisposition To Acute Myelogenous Leukemia Hereditary Thrombocytopenia With Normal Platelets-Hematological Cancer Predisposition Syndrome Runx1 Fpd/Aml
Differentiated Thyroid Carcinoma	Papillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Congenital Fibrosarcoma	Infantile Fibrosarcoma
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Mammary Analogue Secretory Carcinoma
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Childhood Acute Lymphocytic Leukemia	Childhood Acute Lymphoblastic Leukemia Childhood All Pediatric Acute Lymphoblastic Leukemia Lymphoblastic Leukemia Acute Childhood
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Myeloproliferative Disorder, Chronic, With Eosinophilia	Myeloproliferative Disorder With Eosinophilia MPE Emp Eosinophils, Malignant Proliferation Of Chronic Myeloproliferative Disorder With Eosinophilia Chronic Myeloproliferative Disease, Unclassifiable Cmpd-U Undifferentiated Myeloproliferative Disease Myeloproliferative Disorder Chronic With Eosinophilia Malignant Proliferation Of Eosinophils Myeloproliferative Neoplasm, Unclassifiable
Nephroma	Benign Nephroma
Testicular Leukemia
Childhood Fibrosarcoma	Pediatric Fibrosarcoma
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Salivary Gland Carcinoma	Salivary Gland Cancer Malignant Neoplasm Of Salivary Gland Salivary Gland Neoplasms
Breast Secretory Carcinoma	Secretory Breast Carcinoma Juvenile Breast Carcinoma Juvenile Carcinoma Of The Breast Juvenile Secretory Carcinoma Of Breast Juvenile Breast Cancer Sbc Secretory Carcinoma Of The Breast
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Cellular Congenital Mesoblastic Nephroma
Adult Fibrosarcoma
B-Lymphoblastic Leukemia/Lymphoma With Iamp21	B-All With Iamp21 Intrachromosomal Amplification Of Chromosome 21
B-Lymphoblastic Leukemia/Lymphoma With Etv6-Runx1	B-All With Etv6-Runx1 B-Lymphoblastic Leukemia/Lymphoma With T(12 21)(P13.2 Q22.1) Etv6-Runx1 B Lymphoblastic Leukemia/Lymphoma With T(12 21)(P13.2 Q22.1) Etv6-Runx1
Salivary Gland Mucinous Adenocarcinoma
Kidney Cortex Disease
Childhood B-Cell Acute Lymphoblastic Leukemia	B-Cell Childhood Acute Lymphoblastic Leukemia
B-Lymphoblastic Leukemia/Lymphoma With Hypodiploidy	B-All With Hypodiploidy Hypodiploid All
Fasciitis
Childhood Leukemia
Lipofibromatosis-Like Neural Tumor
Salivary Gland Disease	Salivary Gland Disorders Salivary Gland Diseases Non-Neoplastic Salivary Gland Disease Non-Neoplastic Salivary Gland Disorder Disorder Of Salivary Gland Lesion Of Salivary Gland Nos
Parotid Gland Cancer	Cancer Of Parotid Gland Parotid Neoplasms Malignant Neoplasm Of The Parotid Malignant Tumor Of Parotid Gland Parotid Cancer Parotid Neoplasm Parotid Gland Carcinoma Cancer Of Parotid Malignant Tumour Of Parotid Gland Parotid Duct Cancer Parotid Ductal Cancer Parotid Glandular Cancer Primary Malignant Neoplasm Of Parotid Gland
Acinar Cell Carcinoma	Acinic Cell Carcinoma Acinic Cell Tumor Carcinoma Acinar Cell Carcinoma, Acinar Cell Acinar Cell Tumor
Infantile Myofibromatosis	Lipofibromatosis Myofibromatosis
Chronic Eosinophilic Leukemia	Pdgfra-Associated Chronic Eosinophilic Leukemia
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Epithelial-Myoepithelial Carcinoma	Clear Cell Adenoma Adenomyo-Epithelioma Clear Cell Carcinoma Emc Epithelial Myoepithelial Carcinoma Glycogen-Rich Adenocarcinoma Glycogen-Rich Adenoma Monomorphic Clear Cell Tumor Tubular Solid Adenoma Adenocarcinoma, Clear Cell
Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement	Myeloid/Lymphoid Neoplasm Associated With Pdgfra Rearrangement Myeloid And Lymphoid Neoplasms With Pdgfra Rearrangement
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Pregnancy Adenoma	Lactating Adenoma
Adult Acute Lymphocytic Leukemia	Adult Acute Lymphoid Leukemia Adult All
B-Lymphoblastic Leukemia/Lymphoma With Hyperdiploidy	B-All With Hyperdiploidy B Lymphoblastic Leukemia Lymphoma With Hyperdiploidy
Diamond-Blackfan Anemia 11	DBA11 Rpl26-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 11
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Atypical Chronic Myeloid Leukaemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Acute Biphenotypic Leukemia	Mixed Phenotype Acute Leukemia Acute Leukemia Of Ambiguous Lineage Acute Undifferentiated Leukemia Acute Leukemia Of Indeterminate Lineage Hybrid Acute Leukemia Mixed Lineage Acute Leukemia All With Myeloid Markers Aml With Lymphoid Markers Acute Leukemia Of Undetermined Lineage Bal Biphenotypic Acute Leukemia Undifferentiated Acute Leukemia Mpal Acute Myeloid Leukemia, Minimal Differentiation, Fab M0 Leukemia, Biphenotypic, Acute
Tonsil Cancer	Tonsillar Neoplasms Malignant Neoplasm Of Faucial Tonsil Malignant Neoplasm Of Palatine Tonsil Malignant Neoplasm Of Tonsil, Faucial Malignant Tonsillar Tumor Malignant Tumor Of Tonsil Tonsillar Carcinoma Malignant Neoplasm Tonsil
Pleomorphic Adenoma Carcinoma	Carcinoma Ex Pleomorphic Adenoma Carcinoma In Pleomorphic Adenoma
Acute Myelomonocytic Leukemia	Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16 16)(P13 Q22) Aml M4 Ammol Acute Myeloblastic Leukemia Type 4 Aml With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16 16)(P13 Q22) Aml-M4 Aml With Inv(16)(P13.1q22) Or T(16 16)(P13.1 Q22) Cbfb-Myh11 Leukemia Myelomonocytic Acute Leukemia, Myelomonocytic, Acute Acute Myelomonocytic Leukaemia Without Mention Of Remission Myelomonocytic Leukaemia Nos
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1	B-All With Bcr-Abl1 B-Lymphoblastic Leukemia/Lymphoma With T(9 22)(Q34.1 Q11.2) Bcr-Abl1 B Lymphoblastic Leukemia/Lymphoma With T(9 22)(Q34.1 Q11.2) Bcr-Abl1
Ectomesenchymoma	Rhabdomyosarcoma With Ganglionic Differentiation Malignant Ectomesenchymoma
Central Nervous System Mesenchymal Non-Meningothelial Tumor	Central Nervous System Mesenchymal Non-Meningothelial Tumour Non-Meningothelial Mesenchymal Tumor Non-Meningothelial Mesenchymal Tumour
Kidney Benign Neoplasm	Renal And Ureteral Tumor Benign Kidney Neoplasm
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic-Myeloproliferative Diseases Myelodysplastic/Myeloproliferative Disease Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Adult Teratoma
Acute Basophilic Leukemia
Central Nervous System Leukemia	Leukemia Of The Cns
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Breast Adenoid Cystic Carcinoma	Adenoid Cystic Breast Carcinoma Adenoid Cystic Carcinoma Of Breast Mammary Adenocystic Carcinoma
Lipid-Rich Carcinoma
Myofibroma	Lipoleiomyoma Uterine Fibroids Solitary Myofibromatosis Myolipoma
Mixed Lacrimal Gland Cancer	Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland Malignant Mixed Neoplasm Of Lacrimal Gland
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Autosomal Dominant Intellectual Developmental Disorder 8	Autosomal Dominant Non-Syndromic Intellectual Disability 8 Mental Retardation, Autosomal Dominant 8 Autosomal Dominant Mental Retardation 8 Mrd8
Oropharynx Cancer	Oropharyngeal Cancer Oropharyngeal Carcinoma Malignant Neoplasm Of Oropharynx Malignant Oropharyngeal Tumor Malignant Tumor Of Oropharynx Malignant Tumour Of Mesopharynx Oropharyngeal Cancer, Adult Cancer Of The Oropharynx
Amegakaryocytic Thrombocytopenia, Congenital	Congenital Amegakaryocytic Thrombocytopenia CAMT Thrombocytopenia, Congenital Amegakaryocytic Congenital Amegakaryocytic Thrombocytopenic Purpura Thrombocytopenia Congenital Amegakaryocytic Thrombocytopenia, Amegakaryocytic, Congenital
Spindle Cell Sarcoma	Sarcoma Sarcoma Spindle Cell Sarcoma, Spindle Cell Sarcoma - Category
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Breast Juvenile Papillomatosis	Juvenile Papillomatosis Of The Breast
Chromosomal Duplication Syndrome
Kidney Fibrosarcoma	Fibrosarcoma Of The Kidney
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146807	Type II TRK inhibitor 1	Inhibitor	/	Unkown
HY-155046	FGFR4-IN-14	Inhibitor	/	Unkown
HY-163366	TRK-IN-28	Inhibitor	/	Unkown
HY-184598	CYB-5067		/	Unkown
HY-RS04569	ETV6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19598	Etv6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26094	Etv6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ETV6	VGNC	VGNC:72444
Mus musculus	ETV6	MGD	MGI:109336
Rattus norvegicus	ETV6	RGD	RGD:1559537
Canis familiaris	ETV6	VGNC	VGNC:40500
Bos taurus	ETV6	VGNC	VGNC:28632
Felis catus	ETV6	VGNC	VGNC:61986
Others	ETV6	NCBI