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ZFP36L1 - ZFP36 ring finger protein like 1 Gene

Also Known as BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 677

About ZFP36L1

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:68,787,655-68,796,243 (from NCBI)

This gene has 6 transcripts (splice variants), 247 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 164.2), ovary (RPKM 123.6) and 25 other tissues.

Summary

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in Other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

ZFP36L1 Products (3)

mRNA	Protein	Name
NM_001244698.2	NP_001231627.1	mRNA decay activator protein ZFP36L1 isoform 1
NM_001244701.1	NP_001231630.1	mRNA decay activator protein ZFP36L1 isoform 2
NM_004926.4	NP_004917.2	mRNA decay activator protein ZFP36L1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	15538381	GOA
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	12198173	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	15467755	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15687258	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: Inferred from direct assay	15467755	GOA
involved in 3'-UTR-mediated mRNA destabilization	IMP IMP: Inferred from mutant phenotype	12198173	GOA
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	25106868	GOA
involved in MAPK cascade	IDA IDA: Inferred from direct assay	18326031	GOA
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	19179481	GOA
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to glucocorticoid stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	21832157	GOA
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	15538381	GOA
involved in cellular response to peptide hormone stimulus	IDA IDA: Inferred from direct assay	15467755	GOA
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	20166898	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	20166898	GOA
involved in mRNA transport	IMP IMP: Inferred from mutant phenotype	17369404	GOA
involved in negative regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	20702587	GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15538381	GOA
involved in positive regulation of intracellular mRNA localization	IMP IMP: Inferred from mutant phenotype	17369404	GOA
involved in positive regulation of monocyte differentiation	IDA IDA: Inferred from direct assay	26542173	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	20166898	GOA
involved in regulation of keratinocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	27182009	GOA
involved in regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	27182009	GOA
involved in regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	27182009	GOA
involved in regulation of mRNA 3'-end processing	IDA IDA: Inferred from direct assay	21832157	GOA
acts upstream of or within regulation of mRNA stability	IDA IDA: Inferred from direct assay	15467755	GOA
involved in regulation of mRNA stability	IDA IDA: Inferred from direct assay	15538381	GOA
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	12198173	GOA
involved in response to wounding	IDA IDA: Inferred from direct assay	27182009	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	17369404	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12198173	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12198173	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	15687258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFP36L1 Protein Structure

Tis11B_N

zf-CCCH

0
100
200
300
338 a.a.

Protein Preferred Names	Protein Names
mRNA decay activator protein ZFP36L1	EGF-response factor 1

ZFP36L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZFP36L1	Q07352	YWHAG	Homo sapiens	P61981	SLC	36931259
Intra	ZFP36L1	Q07352	MAPK14	Homo sapiens	Q16539	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16041	ZFP36L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21270	Zfp36l1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27788	Zfp36l1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZFP36L1	VGNC	VGNC:99347
Canis familiaris	ZFP36L1	VGNC	VGNC:48613
Mus musculus	ZFP36L1	MGD	MGI:107946
Felis catus	ZFP36L1	VGNC	VGNC:67231
Bos taurus	ZFP36L1	VGNC	VGNC:37163
Rattus norvegicus	ZFP36L1	RGD	RGD:62009
Others	ZFP36L1	NCBI