Helenalin acetate
Based on 2 publication(s) in Google Scholar
Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities.
For research use only. We do not sell to patients.
- Purity : 99.55%
- CAS No.: 10180-86-6
- Formula: C17H20O5
- Molecular Weight:304.34
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Helenalin acetate
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEp-2 | ED50 |
0.29 μg/mL
Compound: 4
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Cytotoxicity against human Hep2 cells assessed as growth inhibition by microtiter method
Cytotoxicity against human Hep2 cells assessed as growth inhibition by microtiter method
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[PMID: 671468] |
In Vitro
Helenalin acetate (0.1-1 μM; for 7 days) inhibits the differentiation significantly in 3T3-L1 cells[1].
Helenalin acetate exerts anti-proliferative effects in acute myeloid leukemia cells but not in normal hematopoietic progenitor cells[1].
Helenalin acetate inhibits C/EBPβ by binding to the N-terminal part of C/EBPβ, thereby disrupting the cooperation of C/EBPβ with the co-activator p300. Helenalin acetate selectively inhibits only the full-length (liver-enriched activating protein* (LAP*)) isoform but not the slightly shorter (LAP) isoform[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:3T3-L1 cells
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Concentration:0.1 μM, 0.3 μM, 1 μM
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Incubation Time:for 7 days
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Result:Inhibited the differentiation significantly.
Chemical Information
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CAS No. 10180-86-6
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Appearance Solid
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Molecular Weight 304.34
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Formula C17H20O5
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Color White to off-white
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SMILES
CC(O[C@@H]1[C@]2([C@](C=CC2=O)([H])[C@@H](C[C@@H]3[C@H]1C(C(O3)=O)=C)C)C)=O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Lett
Targeting TAM-secreted S100A9 effectively enhances the tumor-suppressive effect of metformin in treating lung adenocarcinoma. [Abstract]2024 Jan 28:581:216497. PMID: 38008395 -
Mol Hum Reprod
2025 Jul 3;31(3):gaaf031. PMID: 40632597
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Helenalin acetate Related Classifications
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