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Cat. No.: HY-149951

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Anticancer agent 107

Anticancer agent 107(Compd 11jc) has significant antitumor activity and can be used as an anticancer agent in the study of pulmonary metastatic melanoma.

For research use only. We do not sell to patients.

CAS No.: 2397573-96-3
Formula: C₂₄H₁₉N₃O₄S
Molecular Weight:445.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Anticancer agent 107 Chemical Structure

CAS No.: 2397573-96-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Anticancer agent 107(Compd 11jc) has significant antitumor activity and can be used as an anticancer agent in the study of pulmonary metastatic melanoma^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	8.8 μM Compound: 11jc	Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis	[PMID: 37084598]
B16-F10	IC₅₀	6.2 μM Compound: 11jc	Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis	[PMID: 37084598]
CT26	IC₅₀	9.3 μM Compound: 11jc	Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis	[PMID: 37084598]
MEF	IC₅₀	>100 μM Compound: 11jc	Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis	[PMID: 37084598]

Chemical Information

CAS No. 2397573-96-3
Molecular Weight 445.49
Formula C₂₄H₁₉N₃O₄S
SMILES

N#CC(C/1=O)=C(NC(C2=C3SC4=C2CCCCC4)=O)N3C1=C\C(C5=CC=C(OC)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Anna Rogova, et al. Synthesis of thieno[3,2-e]pyrrolo[1,2-a]pyrimidine derivatives and their precursors containing 2-aminothiophenes fragments as anticancer agents for therapy of pulmonary metastatic melanoma. Eur J Med Chem. 2023 Jun 5;254:115325. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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