Cat. No.: HY-146290

Anticancer agent 45

Anticancer agent 46 (compound 2b) is a potent and selective anticancer agent. Anticancer agent 46 shows cytotoxicity activity in cancer cells. Anticancer agent 46 induces apoptosis. Anticancer agent 46 shows low toxicity towards activated lymphocytes of human blood.

For research use only. We do not sell to patients.

CAS No.: 2770943-87-6
Formula: C₂₂H₁₄ClN₃O₆S₂
Molecular Weight:515.95

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Anticancer agent 45 Chemical Structure

CAS No.: 2770943-87-6

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Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	1.23 μM Compound: 2b	Anticancer activity against human 786-0 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human 786-0 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
A549	GI₅₀	3.11 μM Compound: 2b	Anticancer activity against human A549 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human A549 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
A549	GI₅₀	7.25 μM Compound: 2b	Anticancer activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
ACHN	GI₅₀	1.36 μM Compound: 2b	Anticancer activity against human ACHN cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human ACHN cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
BALB/3T3	IC₅₀	>100 μM Compound: Les-6287	Cytotoxicity against mouse BALB/3T3 cells assessed reduction in cellular metabolic activity incubated for 24 to 72 hrs by MTT assay Cytotoxicity against mouse BALB/3T3 cells assessed reduction in cellular metabolic activity incubated for 24 to 72 hrs by MTT assay	[PMID: 37579525]
Breast carcinoma cell	IC₅₀	1 μM Compound: Les-6287	Cytotoxicity against human Breast carcinoma cell assessed as inhibition of cell growth measured at 72 hrs Cytotoxicity against human Breast carcinoma cell assessed as inhibition of cell growth measured at 72 hrs	[PMID: 37579525]
BT-549	GI₅₀	2.03 μM Compound: 2b	Anticancer activity against human BT-549 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human BT-549 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
CAKI-1	GI₅₀	1.15 μM Compound: 2b	Anticancer activity against human CAKI-1 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human CAKI-1 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
CCRF-CEM	GI₅₀	0.385 μM Compound: 2b	Anticancer activity against human CCRF-CEM cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human CCRF-CEM cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
COLO 205	GI₅₀	1.83 μM Compound: 2b	Anticancer activity against human COLO 205 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human COLO 205 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
Colon carcinoma cell	IC₅₀	1 μM Compound: Les-6287	Cytotoxicity against human Colon carcinoma cell assessed as inhibition of cell growth measured at 72 hrs Cytotoxicity against human Colon carcinoma cell assessed as inhibition of cell growth measured at 72 hrs	[PMID: 37579525]
DU-145	GI₅₀	1.72 μM Compound: 2b	Anticancer activity against human DU-145 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human DU-145 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
EKVX	GI₅₀	3.25 μM Compound: 2b	Anticancer activity against human EKVX cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human EKVX cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
Glioblastoma cell line	IC₅₀	1 μM Compound: Les-6287	Cytotoxicity against human Glioblastoma cell line assessed as inhibition of cell growth measured at 72 hrs Cytotoxicity against human Glioblastoma cell line assessed as inhibition of cell growth measured at 72 hrs	[PMID: 37579525]
HaCaT	GI₅₀	73.6 μM Compound: 2b	Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
HaCaT	IC₅₀	>100 μM Compound: Les-6287	Cytotoxicity against human HaCaT cells assessed reduction in cellular metabolic activity incubated for 24 to 72 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed reduction in cellular metabolic activity incubated for 24 to 72 hrs by MTT assay	[PMID: 37579525]
HaCaT	IC₅₀	73.6 μM Compound: Les-6287	Cytotoxicity against human HaCaT cells assessed reduction in cellular metabolic activity incubated for 72 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed reduction in cellular metabolic activity incubated for 72 hrs by MTT assay	[PMID: 37579525]
HCC 2998	GI₅₀	1.48 μM Compound: 2b	Anticancer activity against human HCC 2998 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HCC 2998 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
HCT-116	GI₅₀	0.751 μM Compound: 2b	Anticancer activity against human HCT-116 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HCT-116 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
HCT-116	GI₅₀	4.52 μM Compound: 2b	Anticancer activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
HCT-15	GI₅₀	0.472 μM Compound: 2b	Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HCT-15 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
HeLa	GI₅₀	6.13 μM Compound: 2b	Anticancer activity against human HeLa cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human HeLa cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
HL-60	GI₅₀	2.44 μM Compound: 2b	Anticancer activity against human HL-60 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HL-60 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
HOP-62	GI₅₀	2.26 μM Compound: 2b	Anticancer activity against human HOP-62 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HOP-62 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
HOP-92	GI₅₀	1.62 μM Compound: 2b	Anticancer activity against human HOP-92 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HOP-92 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
Hs-578T	GI₅₀	2.8 μM Compound: 2b	Anticancer activity against human Hs-578T cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human Hs-578T cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
HT-29	GI₅₀	0.847 μM Compound: 2b	Anticancer activity against human HT-29 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human HT-29 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
IGROV-1	GI₅₀	1.2 μM Compound: 2b	Anticancer activity against human IGROV-1 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human IGROV-1 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
Jurkat	GI₅₀	1.3 μM Compound: 2b	Anticancer activity against human Jurkat cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human Jurkat cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
K562	GI₅₀	0.603 μM Compound: 2b	Anticancer activity against human K562 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human K562 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
KB 3-1	GI₅₀	8 μM Compound: 2b	Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
KM12	GI₅₀	1.83 μM Compound: 2b	Anticancer activity against human KM12 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human KM12 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
Leukemic tumor cell line	IC₅₀	1 μM Compound: Les-6287	Cytotoxicity against human Leukemic tumor cell line assessed as inhibition of cell growth measured at 72 hrs Cytotoxicity against human Leukemic tumor cell line assessed as inhibition of cell growth measured at 72 hrs	[PMID: 37579525]
Lung cancer cell line	IC₅₀	1 μM Compound: Les-6287	Cytotoxicity against human Lung cancer cell line assessed as inhibition of cell growth measured at 72 hrs Cytotoxicity against human Lung cancer cell line assessed as inhibition of cell growth measured at 72 hrs	[PMID: 37579525]
Lymphocyte	GI₅₀	51.2 μM Compound: 2b	Cytotoxicity against mitogen activated human peripheral blood lymphocytes assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against mitogen activated human peripheral blood lymphocytes assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 35533562]
Lymphocyte	GI₅₀	67.1 μM Compound: 2b	Cytotoxicity against mitogen activated human peripheral blood lymphocytes assessed as cell growth inhibition incubated for 24 hrs by MTT assay Cytotoxicity against mitogen activated human peripheral blood lymphocytes assessed as cell growth inhibition incubated for 24 hrs by MTT assay	[PMID: 35533562]
M14	GI₅₀	1.46 μM Compound: 2b	Anticancer activity against human M14 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human M14 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
Malme-3M	GI₅₀	2.31 μM Compound: 2b	Anticancer activity against human Malme-3M cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human Malme-3M cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
MCF7	GI₅₀	1.21 μM Compound: 2b	Anticancer activity against human MCF7 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MCF7 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
MCF7	GI₅₀	4 μM Compound: 2b	Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
MDA-MB-231	GI₅₀	2.14 μM Compound: 2b	Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
MDA-MB-231	GI₅₀	6.2 μM Compound: 2b	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
MDA-MB-435	GI₅₀	2.01 μM Compound: 2b	Anticancer activity against human MDA-MB-435 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MDA-MB-435 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
MDA-MB-468	GI₅₀	1.87 μM Compound: 2b	Anticancer activity against human MDA-MB-468 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MDA-MB-468 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
MOLT-4	GI₅₀	0.534 μM Compound: 2b	Anticancer activity against human MOLT-4 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human MOLT-4 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
NCI/ADR-RES	GI₅₀	2.13 μM Compound: 2b	Anticancer activity against human NCI/ADR-RES cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI/ADR-RES cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
NCI-H226	GI₅₀	2.41 μM Compound: 2b	Anticancer activity against human NCI-H226 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H226 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
NCI-H23	GI₅₀	1.56 μM Compound: 2b	Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H23 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
NCI-H322M	GI₅₀	2.34 μM Compound: 2b	Anticancer activity against human NCI-H322M cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H322M cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
NCI-H460	GI₅₀	2.55 μM Compound: 2b	Anticancer activity against human NCI-H460 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H460 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
NCI-H522	GI₅₀	1.86 μM Compound: 2b	Anticancer activity against human NCI-H522 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human NCI-H522 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
OVCAR-3	GI₅₀	0.604 μM Compound: 2b	Anticancer activity against human OVCAR-3 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human OVCAR-3 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
OVCAR-4	GI₅₀	5.13 μM Compound: 2b	Anticancer activity against human OVCAR-4 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human OVCAR-4 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
OVCAR-5	GI₅₀	1.91 μM Compound: 2b	Anticancer activity against human OVCAR-5 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human OVCAR-5 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
OVCAR-8	GI₅₀	2.16 μM Compound: 2b	Anticancer activity against human OVCAR-8 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human OVCAR-8 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
PC-3	GI₅₀	0.906 μM Compound: 2b	Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human PC-3 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
RPMI-8226	GI₅₀	0.295 μM Compound: 2b	Anticancer activity against human RPMI-8226 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human RPMI-8226 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
RXF 393	GI₅₀	1.53 μM Compound: 2b	Anticancer activity against human RXF 393 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human RXF 393 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SCC-15	EC₅₀	24.85 μM Compound: Les-6287	Cytotoxicity against human SCC-15 cells assessed as LDH release incubated for 24 hrs Cytotoxicity against human SCC-15 cells assessed as LDH release incubated for 24 hrs	[PMID: 37579525]
SCC-15	EC₅₀	32.75 μM Compound: Les-6287	Cytotoxicity against human SCC-15 cells assessed as LDH release incubated for 48 hrs Cytotoxicity against human SCC-15 cells assessed as LDH release incubated for 48 hrs	[PMID: 37579525]
SCC-15	IC₅₀	17.69 μM Compound: Les-6287	Cytotoxicity against human SCC-15 cells assessed as decrease in cellular metabolic activity incubated for 24 hrs by resazurin reduction assay Cytotoxicity against human SCC-15 cells assessed as decrease in cellular metabolic activity incubated for 24 hrs by resazurin reduction assay	[PMID: 37579525]
SCC-15	IC₅₀	6.72 μM Compound: Les-6287	Cytotoxicity against human SCC-15 cells assessed as decrease in cellular metabolic activity incubated for 48 hrs by resazurin reduction assay Cytotoxicity against human SCC-15 cells assessed as decrease in cellular metabolic activity incubated for 48 hrs by resazurin reduction assay	[PMID: 37579525]
SF-268	GI₅₀	2.43 μM Compound: 2b	Anticancer activity against human SF-268 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SF-268 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SF-295	GI₅₀	1.31 μM Compound: 2b	Anticancer activity against human SF-295 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SF-295 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SF-539	GI₅₀	1.72 μM Compound: 2b	Anticancer activity against human SF-539 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SF-539 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SK-MEL-2	GI₅₀	2.74 μM Compound: 2b	Anticancer activity against human SK-MEL-2 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SK-MEL-2 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SK-MEL-28	GI₅₀	1.95 μM Compound: 2b	Anticancer activity against human SK-MEL-28 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SK-MEL-28 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SK-MEL-5	GI₅₀	1.92 μM Compound: 2b	Anticancer activity against human SK-MEL-5 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SK-MEL-5 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SK-OV-3	GI₅₀	>100 μM Compound: 2b	Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
SK-OV-3	GI₅₀	2.99 μM Compound: 2b	Anticancer activity against human SK-OV-3 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SK-OV-3 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SN12C	GI₅₀	1.6 μM Compound: 2b	Anticancer activity against human SN12C cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SN12C cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SNB-19	GI₅₀	1.34 μM Compound: 2b	Anticancer activity against human SNB-19 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SNB-19 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SR	GI₅₀	0.394 μM Compound: 2b	Anticancer activity against human SR cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SR cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
SW-620	GI₅₀	0.684 μM Compound: 2b	Anticancer activity against human SW-620 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human SW-620 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
T47D	GI₅₀	2.45 μM Compound: 2b	Anticancer activity against human T47D cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human T47D cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
TK-10	GI₅₀	1.92 μM Compound: 2b	Anticancer activity against human TK-10 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human TK-10 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
U-251	GI₅₀	0.597 μM Compound: 2b	Anticancer activity against human U-251 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human U-251 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
U-251	GI₅₀	1.1 μM Compound: 2b	Anticancer activity against human U-251 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Anticancer activity against human U-251 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 35533562]
UACC-257	GI₅₀	2.48 μM Compound: 2b	Anticancer activity against human UACC-257 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human UACC-257 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
UACC-62	GI₅₀	1.67 μM Compound: 2b	Anticancer activity against human UACC-62 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human UACC-62 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]
UO-31	GI₅₀	1.35 μM Compound: 2b	Anticancer activity against human UO-31 cells assessed as growth inhibition incubated for 48 hrs by SRB assay Anticancer activity against human UO-31 cells assessed as growth inhibition incubated for 48 hrs by SRB assay	[PMID: 35533562]

In Vitro

Anticancer agent 46 (compound 2b) (0-100 µM; 72 h) shows antitumor activity with GI₅₀S of 1.30, 7.25, 4.00, 6.20, 8.00, 6.13, 4.52, 5.65, 1.10, >100, 73.62 µM for Jurkat, A549, MCF-7, MDA-MB-231, KB3-1, HeLa, HCT-116, HCT-116 p53-/-, U251, SK-OV-3, HaCaT cells, respectively^[1].
Anticancer agent 46 (1.5 µM; 24 h) induces apoptosis by increases the expression of caspase 3, Bax and decreases the amount of anti-apoptotic Bcl-2 protein^[1].
Anticancer agent 46 (compound 2b) (0-2 µM; 24, 48 h) shows low toxicity towards normal human keratinocytes of HaCaT line and mitogen-activated lymphocytes of peripheral blood of healthy human donor^[1].
Anticancer agent 46 dose not induce significant DNA damage and changes in morphology of mitogen-activated lymphocytes of peripheral blood of healthy donor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Jurkat cells
Concentration:

1.5 µM
Incubation Time:

24 h
Result:

Increased in the amount of pro-apoptotic proteins: caspase 3, Bax, and decreased the amount of anti-apoptotic Bcl-2 protein.

Chemical Information

CAS No. 2770943-87-6
Molecular Weight 515.95
Formula C₂₂H₁₄ClN₃O₆S₂
SMILES

O=C(C(N(C/1=O)C(SC1=C/C(Cl)=C/C2=CC=C([N+]([O-])=O)C=C2)=S)C3)N(C4=CC=C(O)C=C4)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Finiuk N, et al. Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation. Eur J Med Chem. 2022 May 2;238:114422. [Content Brief]

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