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Cat. No.: HY-157828

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DSP-0390

DSP-0390 is an orally active inhibitor of emopamil binding protein (EBP). DSP-0390 induces cell death by blocking cholesterol biosynthesis in tumor cells. DSP-0390 exhibits antitumor activity in an orthotopic xenograft model of human glioblastoma. DSP-0390 can be used for the research of recurrent high-grade gliomas.

For research use only. We do not sell to patients.

CAS No.: 2376765-57-8
Formula: C₂₃H₃₀ClN₃O₂
Molecular Weight:415.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DSP-0390 Chemical Structure

CAS No.: 2376765-57-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

DSP-0390 inhibits the key late-stage steps of de novo cholesterol biosynthesis and exerts cytotoxicity against hyperproliferative cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2376765-57-8
Molecular Weight 415.96
Formula C₂₃H₃₀ClN₃O₂
SMILES

CC1([C@]2([H])CC3(CCN(CC3)CCN4C=CN=C4)CO[C@@]2([H])C5=CC=C(Cl)C=C5O1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. David A. Reardon et al. DSP-0390, an oral emopamil binding protein (EBP) inhibitor, in patients with recurrent high-grade glioma: A first-in-human, phase 1 study.. J Clin Oncol 40, TPS2077-TPS2077(2022).

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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