country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

ARF4 - ADP ribosylation factor 4 Gene

Also Known as ARF2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 378

About ARF4

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:57,571,363-57,597,344 (from NCBI)

This gene has 9 transcripts (splice variants), 147 orthologues and 30 paralogues. Ubiquitous expression in gall bladder (RPKM 100.9), placenta (RPKM 94.0) and 25 other tissues.

Summary

This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of Phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the Ras superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]

ARF4 Products (1)

mRNA	Protein	Name
NM_001660.4	NP_001651.1	ADP-ribosylation factor 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	12446727	GOA
enables NAD+-protein-arginine ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	1899243	GOA
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	12446727	GOA
enables phospholipase D activator activity	IDA IDA: Inferred from direct assay	12446727	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17956946	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IDA IDA: Inferred from direct assay	22004728	GOA
acts upstream of or within dendritic spine development	IDA IDA: Inferred from direct assay	23050017	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19041174	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12446727	GOA
involved in regulation of cilium assembly	IDA IDA: Inferred from direct assay	25673879	GOA
involved in regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19041174	GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IGI IGI: Inferred from genetic interaction	24768165	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	25673879	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12446727	GOA
located in dendritic spine	IDA IDA: Inferred from direct assay	23050017	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	12446727	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARF4 Protein Structure

Arf

0
100
180 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor 4	ADP-ribosylation factor 2

ARF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARF4	P18085	COPS3	Homo sapiens	Q9UNS2	Validated Y2H	32296183
Intra	ARF4	P18085	COPS3	Homo sapiens	Q9UNS2	Y2H Prey Pooling	32296183
Intra	ARF4	P18085	COPS3	Homo sapiens	Q9UNS2	Y2H Array	32296183
Intra	ARF4	P18085	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	25416956
Intra	ARF4	P18085	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

ARF4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811015	ARF4 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Chromosome 17q21.31 Duplication Syndrome	17q21.31 Microduplication Syndrome Trisomy 17q21.31 Dup(17)(Q21.31)
Retinitis Pigmentosa 7	Leber Congenital Amaurosis 18 RP7 Retinitis Pigmentosa 7, Digenic Form Retinitis Pigmentosa 7 And Digenic Form Retinitis Pigmentosa 7, Digenic LCA18 Retinitis Pigmentosa 7 Digenic
Retinitis Pigmentosa 2	RP2 X-Linked Retinitis Pigmentosa 2 Xlrp2 Xlrp-2 Retinitis Pigmentosa-2 Retinitis Pigmentosa, Type 2
Periventricular Nodular Heterotopia	Periventricular Heterotopia Pvnh Familial Nodular Heterotopia Heterotopia, Periventricular Periventricular Heterotopia, X-Linked
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00896	ARF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARF4	VGNC	VGNC:26059
Canis familiaris	ARF4	VGNC	VGNC:38030
Rattus norvegicus	ARF4	RGD	RGD:621275
Mus musculus	ARF4	MGD	MGI:99433
Others	ARF4	NCBI