IL22RA1 - interleukin 22 receptor subunit alpha 1 Gene

Also Known as IL22R; CRF2-9; IL22R1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58985

About IL22RA1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,119,771-24,143,140 (from NCBI)

This gene has 1 transcript (splice variant), 231 orthologues and 11 paralogues. Biased expression in pancreas (RPKM 15.5), skin (RPKM 14.3) and 9 other tissues.

Summary

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

IL22RA1 Products (1)

mRNA Protein Name
NM_021258.4 NP_067081.2 interleukin-22 receptor subunit alpha-1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12513909 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL22RA1 Protein Structure

Tissue_fac

Tissue_fac: Tissue factor (15 - 106)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
Protein Preferred Names Protein Names

interleukin-22 receptor subunit alpha-1

  • IL-22 receptor subunit alpha-1

IL22RA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IL22RA1 Q8N6P7 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
IL22RA1 Q8N6P7 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
IL22RA1 Q8N6P7 IL10RB Homo sapiens Q08334
ELISA
15120653
Intra
IL22RA1 Q8N6P7 Q9GZX6-PRO_0000015383 Homo sapiens Q9GZX6-PRO_0000015383
ELISA
15120653
Intra
IL22RA1 Q8N6P7 IL22 Homo sapiens Q9GZX6
GMS
12513909
Intra
IL22RA1 Q8N6P7 IL22 Homo sapiens Q9GZX6
X-Ray Diffraction
18675809
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL22RA1 Proteins

Cat. No. Product Name Accession Purity
HY-P77967 IL-22R alpha 1 Protein, Human (HEK293, Fc) Q8N6P7-1 (H16-T228) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Spondyloarthropathy

  • Spondylarthropathies

  • Spondarthropathy

  • Spondylarthrosis

  • Spondyloarthropathy, Susceptibility To

  • Spondylarthritis
Erythematosquamous Dermatosis

  • Other Erythematosquamous Dermatosis
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06737 IL22RA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174619 Human IL22RA1 mRNA / Unkown
HY-RS21241 Il22ra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27758 Il22ra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990016 Temtokibart Inhibitor 99.23% Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IL22RA1 VGNC VGNC:30144
Canis familiaris IL22RA1 VGNC VGNC:41970
Macaca mulatta IL22RA1 VGNC VGNC:106386
Felis catus IL22RA1 VGNC VGNC:62905
Rattus norvegicus IL22RA1 RGD RGD:1559655
Mus musculus IL22RA1 MGD MGI:2663588
Others IL22RA1 NCBI