TSHR - thyroid stimulating hormone receptor Gene

Also Known as LGR3; CHNG1; hTSHR-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7253

About TSHR

Cytogenetic location: 14q31.1 Genomic coordinates (GRCh38): 14:80,955,621-81,146,306 (from NCBI)

This gene has 12 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 106 phenotypes. Restricted expression toward thyroid (RPKM 104.1).

Summary

The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by Adenylate Cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

TSHR Products (7)

mRNA	Protein	Name
NM_001142626.3	NP_001136098.1	thyrotropin receptor isoform 3 precursor
XM_011537119.3	XP_011535421.1	thyrotropin receptor isoform X1
NM_000369.5	NP_000360.2	thyrotropin receptor isoform 1 precursor
NM_001018036.3	NP_001018046.1	thyrotropin receptor isoform 2
NM_000369.5	NP_000360.2	thyrotropin receptor isoform 1 precursor
NM_001018036.3	NP_001018046.1	thyrotropin receptor isoform 2
NM_001142626.3	NP_001136098.1	thyrotropin receptor isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15775968	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	12045258	GOA
enables signaling receptor activity	IMP IMP: Inferred from mutant phenotype	12045258	GOA
enables thyroid-stimulating hormone receptor activity	IMP IMP: Inferred from mutant phenotype	11847099	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12045258	GOA
involved in cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12045258	GOA
involved in cellular response to glycoprotein	IMP IMP: Inferred from mutant phenotype	12045258	GOA
involved in cellular response to thyrotropin-releasing hormone	IMP IMP: Inferred from mutant phenotype	11847099	GOA
involved in thyroid-stimulating hormone signaling pathway	IMP IMP: Inferred from mutant phenotype	11847099	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11847099	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11847099	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSHR Protein Structure

LRR_8

LRR_5

7tm_1

0
200
400
600
764 a.a.

Protein Preferred Names	Protein Names
thyrotropin receptor	TSH receptor seven transmembrane helix receptor thyrotropin receptor-I, hTSHR-I

TSHR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TSHR	P16473	ADORA1	Homo sapiens	P30542	Anti Tag CoIP	28298427
Intra	TSHR	P16473	SCRIB	Homo sapiens	Q14160	Y2H	15775968
Intra	TSHR	P16473	SYT1	Homo sapiens	P21579	Anti Tag CoIP	28298427
Intra	TSHR	P16473	MID1IP1	Homo sapiens	Q9NPA3	Anti Tag CoIP	28298427

Cross: Cross-species interaction Intra: Intraspecies interaction

TSHR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81507	TSH Receptor/TSH-R Antibody (YA1252)	IHC-P	Human
HY-P81507A	TSH Receptor/TSH-R Antibody (YA1252)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Thyroid Gland Disease	Abnormality Of The Thyroid Gland Thyroid Diseases
Chronic Orbital Inflammation	Chronic Inflammation Of Orbit
Multinodular Goiter
Familial Hyperthyroidism Due To Mutations In Tsh Receptor	Familial Non-Immune Hyperthyroidism Resistance To Thyroid Stimulating Hormone Nonautoimmune Hyperthyroidism Hyperthyroidism, Nonautoimmune
Plummer'S Disease	Toxic Nodular Goiter Plummer Disease Goiter Toxic Nodular
Lagophthalmos	Defective Lid Closure Poor Closure Eyelids
Subacute Thyroiditis	Giant-Cell Thyroiditis Granulomatous Thyroiditis Subacute Granulomatous Thyroiditis De Quervain'S Thyroiditis Thyroiditis Subacute Thyroiditis, Subacute Pseudogranulomatous Thyroiditis De Quervain Thyroiditis Nonsuppurative Subacute Thyroiditis Pseudotuberculous Thyroiditis Nonsuppurative Thyroiditis Nos
Orbital Plasma Cell Granuloma	Orbital Myositis Orbital Pseudotumor Pseudotumor Of Orbit Plasma Cell Granuloma, Orbital
Thyroid Dyshormonogenesis 2a	TDH2A Iodide Peroxidase Deficiency Deficiency Of Iodide Peroxidase Thyroid Peroxidase Deficiency Genetic Defect In Thyroid Hormonogenesis 2a Thyroid Hormonogenesis, Genetic Defect In, 2a Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2a Chdh2a Congenital Hypothyroidism Due To Dyshormonogenesis Type 2a Thyroid Hormone Organification Defect 2 Tiod
Hyperthyroidism, Nonautoimmune	Hyperthyroidism, Congenital Nonautoimmune Hyperthyroidism, Nonautoimmune, Autosomal Dominant Toxic Thyroid Hyperplasia, Autosomal Dominant Nonautoimmune Hyperthyroidism Congenital Nonautoimmune Hyperthyroidism Hyperthyroidism, Non-Autoimmune HTNA Familial Hyperthyroidism Due To Mutations In Tsh Receptor Familial Non-Immune Hyperthyroidism Hyperthyroidism Congenital Non-Autoimmune Hyperthyroidism Non-Autoimmune Autosomal Dominant Resistance To Thyroid Stimulating Hormone Toxic Thyroid Hyperplasia Autosomal Dominant
Hypothyroidism, Congenital, Nongoitrous, 2	Thyroid Dysgenesis CHNG2 Thyroid Hypoplasia Thyroid Hemiagenesis Thyroid Agenesis Athyreotic Hypothyroidism Rtsh Thyrotropin Resistance Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Or Hypoplasia Congenital Nongoitrous Hypothyroidism 2 Thyroid, Ectopic Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Hypothyroidism, Athyreotic Thyrotropin Resistance To Thyrotropin Congenital Hypothyroidism Due To Thyroid Dysgenesis Or Hypoplasia Hypothyroidism, Congenital, Non-Goitrous, 2 Congenital Hypothyroidism Due To Thyroid Dysgenesis Thyroid-Stimulating Hormone Resistance Thyroid Ectopic Ectopic Thyroid Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome Hypothyroidism, Congenital, Nongoitrous, 1
Thyroiditis	Inflammation Of Thyroid Thyroiditis Nos
Exophthalmos	Proptosis
Thyroid Crisis	Thyrotoxic Crisis Thyroid Storm Thyrotoxic Storm
Hyperthyroxinemia
Nontoxic Goiter	Goiter, Non-Toxic Goitre, Non-Toxic Nodule-Thyroid, Non Tox Non-Toxic Goitre Non-Toxic Simple Goitre Goitre Nos Goitre Struma Enlarged Thyroid Gland Thyromegaly Thyroid Hypertrophy Thyroid Gland Hypertrophy Thyroid Hyperplasia Thyroid Gland Hyperplasia Swelling Of Thyroid Gland Substernal Thyroid Mass Substernal Goitre Substernal Thyroid Retrosternal Thyroid Struma Sporadic Nodular Struma Struma Of Thyroid Retrosternal Goitre Plunging Goitre Nontoxic Nodular Goitre Nodular Struma Form Of Goitre Hyperplastic Goitre Hypertrophic Thyroid Intrathoracic Goitre Nodular Goitre
Suppurative Thyroiditis	Thyroiditis, Suppurative Acute Suppurative Thyroiditis Infectious Thyroiditis
Graves' Disease	Graves Disease Exophthalmic Goiter Basedow'S Disease Grave'S Disease Basedow Disease Toxic Diffuse Goiter Graves' Hyperthyroidism Parry Disease Autoimmune Hyperthyroidism Toxic Multinodular Goiter
Follicular Adenoma	Follicular Adenoma Of The Thyroid Gland Thyroid Follicular Adenoma Adenoma Follicular Follicular Thyroid Adenoma Thyroid Gland Follicular Adenoma
Struma Ovarii
Neonatal Thyrotoxicosis
Autoimmune Disease Of Endocrine System
Mucinoses
Myxedema
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Hypothyroidism	Thyroid Diseases Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Disease Thyroid Dysfunction
Hypotropia
Invasive Malignant Thymoma	Infiltrating Thymoma Thymoma Malignant Invasive Invasive Thymoma And Thymic Carcinoma
Orbital Disease	Orbital Diseases Orbit
Endemic Goiter	Iodine-Deficiency-Related Endemic Goitre Simple Goitre Goiter, Endemic Euthyroid Goiter
Hypothyroidism, Congenital, Nongoitrous, 1	Tsh Resistance CHNG1 Hypothyroidism Due To Tsh Receptor Mutations Thyrotropin Resistance Rtsh Hypothyroidism Due To Unresponsiveness To Thyrotropin Congenital Nongoitrous Hypothyroidism 1 Thyroid-Stimulating Hormone Thyroid-Stimulating Hormone, Resistance To Hypothyroidism, Nonautoimmune Hypothyroidism, Congenital, Due To Tsh Resistance Hypothyroidism, Congenital, Non-Goitrous, 1 Congenital Hypothyroidism Due To Tsh Resistance Non-Autoimmune Hypothyroidism Thyroid-Stimulating Hormone Resistance Hypothyroidism, Congenital, Nongoitrous, Type 1 Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome
Thyroid Hormone Resistance, Generalized, Autosomal Dominant	Thyroid Hormone Resistance Syndrome Thyroid Hormone Resistance GRTHD Gthr Thyroid Hormone Unresponsiveness Generalized Thyroid Hormone Resistance Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Thyroid Hormones Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones Refetoff Syndrome Thyroid Hormone Responsiveness Defect Familial Euthyroid Hyperthyroxinemia, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Exposure Keratitis	Exposure Keratoconjunctivitis Lagophthalmic Keratitis
Graves Ophthalmopathy	Graves Orbitopathy Thyroid Associated Ophthalmopathy Thyroid Eye Disease Thyroid-Associated Ophthalmopathy
Thyroid Cancer, Nonmedullary, 2	Thyroid Carcinoma, Follicular Follicular Thyroid Carcinoma NMTC2 Thyroid Cancer, Follicular Thyroid Carcinoma, Follicular, Somatic Ftc Thyroid Cancer, Non-Medullary, 2 Thyroid Follicular Carcinoma Follicular Thyroid Cancer Cancer, Thyroid, Nonmedullary, Type 2 Thyroid Gland Adenocarcinoma Follicular Carcinoma Of Unspecified Site Moderately Differentiated Follicular Carcinoma Of Thyroid Gland Pure Follicle Carcinoma Of Thyroid Gland Pure Follicle Follicular Carcinoma Of Unspecified Site Pure Follicular Carcinoma Of Thyroid Gland Trabecular Follicular Carcinoma Of Thyroid Gland Trabecular Follicular Carcinoma Of Unspecified Site Well Differentiated Follicular Carcinoma Of Unspecified Site Well Differentiated Follicular Carcinoma Of Thyroid Gland
Precocious Puberty, Male-Limited	Testotoxicosis Familial Male-Limited Precocious Puberty Leydig Cell Adenoma, Somatic, With Precocious Puberty FMPP Familial Testotoxicosis Sexual Precocity, Familial, Gonadotropin-Independent Familial Gonadotropin-Independent Male-Limited Sexual Precocity Male-Limited Precocious Puberty Pubertas Praecox Gonadotropin-Independent Familial Sexual Precocity Testotoxicosis, Familial Precocious Puberty, Male Precocious Puberty, Male Limited Familial Gonadotrophin-Independent Sexual Precocity Gipp Gonadotrophin-Independent Precocious Puberty Precocious Pseudopuberty Familial Male Precocious Puberty Precocious Puberty In Males Puberty, Precocious Precocious Puberty
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Subacute Lymphocytic Thyroiditis
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Nodular Goiter	Goiter, Nodular Nodular Goitre Goiter Nodular Non-Toxic Nodular Goiter
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Endocrine Exophthalmos	Endocrine Exopthalmos Thyroid Associated Opthalmopathies
Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate	Bamforth-Lazarus Syndrome Bamforth Syndrome Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Hypothyroidism Cleft Palate Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Athyroidal Hypothyroidism-Spiky Hair-Cleft Palate Syndrome Hypothyroidism-Cleft Palate Syndrome BLS Athyroidal Hypothyroidism With Spiky Hair And Cleft Palate
Goiter	Goitre
Excessive Tearing	Epiphora Lacrimal Apparatus Diseases Excessive Tear Production Watering Eye
Thyroid Gland Follicular Carcinoma	Follicular Thyroid Carcinoma Follicular Adenocarcinoma Follicular Adenocarcinoma, Well Differentiated Follicular Carcinoma Thyroid Adenocarcinoma Adenocarcinoma, Follicular
Hashimoto Thyroiditis	Autoimmune Thyroiditis Hashimoto Struma Hashimoto'S Thyroiditis Chronic Lymphocytic Thyroiditis Lymphocytic Thyroiditis Hashimoto Disease Ht Hashimoto'S Disease Hashimoto'S Syndrome Hypothyroidism, Autoimmune Autoimmune Chronic Lymphocytic Thyroiditis Chronic Lymphocytic Thyroiditides Hashimoto Syndrome Hashimotos Thyroiditis Hashimoto Thyroiditis, Susceptibility To Thyroiditis, Autoimmune Lymphomatous Thyroiditis Lymphoid Thyroiditis Chronic Lymphadenoid Thyroiditis Autoimmune Lymphocytic Chronic Thyroiditis Goitre Lymphomatosa Hashitoxicosis Hashimoto Hypothyroidism Lymphadenoid Goitre Struma Lymphomatosa Hyperthyroidism With Hashimoto Disease Hashimoto Thyrotoxicosis Thyrotoxicosis Due To Hashimoto Thyroiditis Struma Lymphomatosis Lymphadenoid Struma
Iodine Hypothyroidism	Iodine Deficiency Hypothyroidism
Toxic Diffuse Goiter
Graves Disease 1	Thyrotoxicosis Graves Disease, Susceptibility To, 1 GRD1 Grd Hyperthyroidism, Autoimmune Hyperthyroidism Hyperactive Thyroid Gland Overactive Thyroid Toxic Diffuse Goitre Toxic Primary Thyroid Hyperplasia Stokes Disease Thyrotoxicosis With Goitre Thyrotoxicosis Struma Graves Disease Goitre With Hyperthyroidism Basedow Disease Exophthalmic Goitre Exophthalmic Struma Flajani Disease Graves Disease With Exophthalmos Hyperthyroid Goitre Hyperthyroidism Struma Thyroid Exophthalmos Malignant Exophthalmos Parry Disease Toxic Diffuse Goitre With Exophthalmos Toxic Goitre Toxic Goitre Nos Thyrotoxicosis Due To Uninodular Goitre Toxic Thyroid Nodule Toxic Uninodular Goitre Uninodular Toxic Struma Uninodular Toxic Struma With Hyperthyroidism Thyrotoxicosis Due To Single Thyroid Nodule Toxic Uninodular Goitre With Hyperthyroidism Hyperthyroidism With Thyroid Nodule Thyrotoxicosis With Toxic Uninodular Goitre Uninodular Goitre In Hyperthyroidism Uninodular Goitre In Thyrotoxicosis Toxic Multinodular Goitre Multinodular Goitre With Thyrotoxicosis Thyrotoxicosis Nodular Goitre Nodular Goitre With Thyrotoxicosis Adenomatous Goitre With Hyperthyroidism Multinodular Goitre With Hyperthyroidism Nodular Goitre With Hyperthyroidism Nodular Struma With Hyperthyroidism Plummer Disease Thyrotoxicosis Adenomatous Goitre Thyrotoxicosis Adenomatous Struma Toxic Adenomatous Goitre Toxic Adenomatous Struma Toxic Nodular Goitre Nos Toxic Struma Nodosa Toxic Nodular Struma
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Hyperthyroidism, Familial Gestational	Familial Gestational Hyperthyroidism HTFG
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Insulin-Dependent Diabetes Mellitus Type 1 Diabetes T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Hyperthyroidism	Overactive Thyroid
Postsurgical Hypothyroidism	Postoperative Hypothyroidism Post-Surgical Hypothyroidism
Thyrotoxic Exophthalmos
Athyreosis
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107916	Thyrotropin	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12381	ML224	Antagonist	99.18%	Unkown
HY-114116	ML-109	Agonist	99.02%	Unkown
HY-N0526	2"-O-Galloylhyperin		99.57%	Unkown
HY-158100	SYD5115	Antagonist	99.69%	Unkown
HY-114918	MS438	Agonist	99.85%	Unkown
HY-150210	FSHR agonist 1	Agonist	99.45%	Unkown
HY-18286	NCGC00229600	Antagonist	99.67%	Unkown
HY-129995A	TSHR antagonist S37a	Antagonist	98.22%	Unkown
HY-114994	MS437	Activator	98.0%	Unkown
HY-122974	VA-K-14 hydrochloride	Antagonist	98.96%	Unkown
HY-124867	D3-βArr	Modulator	99.49%	Unkown
HY-100271	Org41841	Agonist	99.77%	Unkown
HY-W331198	Tralopyril	Inducer	99.70%	Unkown
HY-153213A	Org 274178-0	Antagonist	99.40%	Unkown
HY-129995	TSHR antagonist S37b	Inhibitor	99.06%	Unkown
HY-169054	NCATS-SM4420		/	Unkown
HY-182705	Org 214444-0		/	Unkown
HY-RS15145	TSHR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15146	Tshr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15147	Tshr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180862	TSHR modulator-1		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991202	Anti-TSHR Antibody (M22)		99.46%	Unkown
HY-P990534	Anti-TSHR Antibody (K1-70)	Inhibitor	98.57%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TSHR	VGNC	VGNC:78662
Canis familiaris	TSHR	VGNC	VGNC:47902
Bos taurus	TSHR	VGNC	VGNC:36419
Mus musculus	TSHR	MGD	MGI:98849
Felis catus	TSHR	VGNC	VGNC:66617
Rattus norvegicus	TSHR	RGD	RGD:3911
Others	TSHR	NCBI