Isovanillin-d3
Based on 1 Customer Validation
Isovanillin-d3 is the deuterium labeled Isovanillin. Isovanillin is an aldehyde oxidase inhibitor. Antispasmodic activities. Antidiarrheal activities.
For research use only. We do not sell to patients.
- CAS No.: 74495-73-1
- Formula: C8H5D3O3
- Molecular Weight:155.17
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 74495-73-1
-
Unlabeled Cas 621-59-0
-
Appearance Solid
-
Molecular Weight 155.17
-
Formula C8H5D3O3
-
SMILES
O=CC1=CC(O)=C(C=C1)OC([2H])([2H])[2H]
-
Synonyms
3-Hydroxy-4-methoxybenzaldehyde-d3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (644.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Panoutsopoulos GI, et al. Enzymatic oxidation of vanillin, isovanillin and protocatechuic aldehyde with freshly prepared Guinea pig liver slices. Cell Physiol Biochem. 2005;15(1-4):89-98. [Content Brief]
[3]. Sadraei H, et al. Antispasmodic activity of isovanillin and isoacetovanillon in comparison with Pycnocycla spinosa Decne.exBoiss extract on rat ileum. Res Pharm Sci. 2014 May-Jun9(3):187-92. [Content Brief]
[4]. Sadraei H, et al. Antidiarrheal activities of isovanillin, iso-acetovanillon and Pycnocycla spinosa Decne ex.Boiss extract in mice. Res Pharm Sci. 2014 Mar-Apr9(2):83-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4445 mL | 32.2227 mL | 64.4454 mL | 161.1136 mL |
| 5 mM | 1.2889 mL | 6.4445 mL | 12.8891 mL | 32.2227 mL | |
| 10 mM | 0.6445 mL | 3.2223 mL | 6.4445 mL | 16.1114 mL | |
| 15 mM | 0.4296 mL | 2.1482 mL | 4.2964 mL | 10.7409 mL | |
| 20 mM | 0.3222 mL | 1.6111 mL | 3.2223 mL | 8.0557 mL | |
| 25 mM | 0.2578 mL | 1.2889 mL | 2.5778 mL | 6.4445 mL | |
| 30 mM | 0.2148 mL | 1.0741 mL | 2.1482 mL | 5.3705 mL | |
| 40 mM | 0.1611 mL | 0.8056 mL | 1.6111 mL | 4.0278 mL | |
| 50 mM | 0.1289 mL | 0.6445 mL | 1.2889 mL | 3.2223 mL | |
| 60 mM | 0.1074 mL | 0.5370 mL | 1.0741 mL | 2.6852 mL | |
| 80 mM | 0.0806 mL | 0.4028 mL | 0.8056 mL | 2.0139 mL | |
| 100 mM | 0.0644 mL | 0.3222 mL | 0.6445 mL | 1.6111 mL |
Powered by Bioz