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Cat. No.: HY-117965

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Miricorilant

(Synonyms: CORT 118335)

Miricorilant (CORT 118335) is a dual selective glucocorticoid (GR) modulator/mineralocorticoid (MR) antagonist. Miricorilant can be used for the research of hypothalamic-pituitary-adrenal (HPA) axis related disorders.

For research use only. We do not sell to patients.

CAS No.: 1400902-13-7
Formula: C₂₄H₂₃F₃N₂O₂
Molecular Weight:428.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Miricorilant Chemical Structure

CAS No.: 1400902-13-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Glucocorticoid/Mineralocorticoid^[1]

In Vivo

CORT 118335 (3-30 mg/kg) potently suppresses endocrine responses to two different stressors (restraint and FST) in male rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats (≈250 g)^[1]
Dosage:

3 mg/kg, 10 mg/kg, 30 mg/kg
Administration:

Subcutaneously (s.c.); five days.
Result:

30 mg/kg had lower corticosterone responses relative to 10 mg/kg at 15 and 30 min time points.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1400902-13-7
Molecular Weight 428.45
Formula C₂₄H₂₃F₃N₂O₂
SMILES

O=C1NC(C(CC2=CC=CC(C(F)(F)F)=C2)=C(N1)[C@H]3CC[C@@H](CC3)C4=CC=CC=C4)=O
Synonyms

CORT 118335
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Elizabeth T Nguyen, et al. A Mixed Glucocorticoid/Mineralocorticoid Receptor Modulator Dampens Endocrine and Hippocampal Stress Responsivity in Male Rats. Physiol Behav. 2017 Sep 1;178:82-92. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

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100 mg

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