RG7112D
RG7112D is a potent MDM2 inhibitor with IC50s of 11 nM and >10000 nM and for MDM2-p53 and VHL-HIF1α by binding HTRF assay, respectively. RG7112D is coupled by an amide bond to VHL-Amine, resulting in a bi-functional molecule, YX-02-030. YX-02-03, a MDM2-PROTAC, potently inhibits MDM2-p53 binding (HTRF IC50=63nM). RG7112D can stabilize MDM2 protein and increase p53 protein levels.
For research use only. We do not sell to patients.
- CAS No.: 2360561-90-4
- Formula: C36H42Cl2N4O4
- Molecular Weight:665.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MDM2 |
Chemical Information
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CAS No. 2360561-90-4
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Molecular Weight 665.65
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Formula C36H42Cl2N4O4
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SMILES
O=C(CN1CCN(CC1)C(N2[C@](C3=CC=C(C=C3)Cl)([C@](C4=CC=C(C=C4)Cl)(N=C2C5=CC=C(C=C5OCC)C(C)(C)C)C)C)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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