STAT3-IN-4
STAT3-IN-4 (compound B9) is a STAT3 inhibitor with Kd values for STAT3 (I634S/Q635G) and WT are 22.75 and 4.59 μM, respectively. STAT3-IN-4 can inhibit the proliferation of tumor cells.
For research use only. We do not sell to patients.
- CAS No.: 825611-06-1
- Formula: C20H13NO5S
- Molecular Weight:379.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
63.77 μM
Compound: B9
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Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human DU-145 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 27727126] |
| MCF7 | IC50 |
133.7 μM
Compound: B9
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 27727126] |
| MDA-MB-231 | IC50 |
13.8 μM
Compound: B9
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Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-231 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 27727126] |
| MDA-MB-468 | IC50 |
5.1 μM
Compound: B9
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Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
Antiproliferative activity against human MDA-MB-468 cells harboring active STAT3 assessed as reduction in cell growth incubated for 24 hrs by CCK8 assay
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[PMID: 27727126] |
Chemical Information
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CAS No. 825611-06-1
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Molecular Weight 379.39
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Formula C20H13NO5S
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SMILES
O=S(C1=CC=C(C(C2=C3C=CC=C2)=O)C(C3=O)=C1)(NC4=CC=C(C=C4)O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STAT3-IN-4 Related Classifications
HY-123524 Related Classifications
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