16-HETE
16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 128914-46-5
- 分子式: C20H32O3
- 分子量:320.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-N0877
Bufalin -
HY-13441
(-)-Blebbistatin -
HY-13719
Oleandrin -
HY-12283
Rostafuroxin -
HY-103265
ARL67156 trisodium -
HY-N0877R
Bufalin (Standard) -
HY-120894
16(R)-HETE -
HY-158623
(±)13(14)-DiHDPA -
HY-142976
Tetranor-12(S)-HETE -
HY-133885
S-(-)-7-Desmethyl-8-nitro blebbistatin -
HY-13719R
Oleandrin (Standard) -
HY-15718
Istaroxime
生物活性
製品説明
体外実験
16-HETE (0.01-1 μM) specificially suppresses PMN aggregation and adhesion, with no significant effects on platelets function and blood pressure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
16-HETE (1 μg/kg/min) suppresses the increase of intracranial pressure (ICP) in a rabbit model of thromboembolic stroke[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand White rabbit[2]
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Dosage:1-20 μg
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Administration:injection into artery
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Result:16S inhibited 60% ATPase activity at the concentration of 2 μM, while 16R enantiomer remained inactive.
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Animal Model:New Zealand White rabbit[1]
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Dosage:1 μg/kg/min
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Administration:6 hours constant infusion from Hours 1 to 2 after autologous clot embolization
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Result:Reduced infarction area and less increased ICP.
化学情報
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CAS 番号 128914-46-5
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分子量 320.47
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分子式 C20H32O3
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SMILES
CCCCC(O)/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Bednar MM, et al., 16(R)-hydroxyeicosatetraenoic acid, a novel cytochrome P450 product of arachidonic acid, suppresses activation of human polymorphonuclear leukocyte and reduces intracranial pressure in a rabbit model of thromboembolic stroke. Neurosurgery. 2000 Dec;47(6):1410-8; discussion 1418-9. [Content Brief]
[2]. Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. [Content Brief]
[3]. Maciejewska D, et al., Metabolites of arachidonic acid and linoleic acid in early stages of non-alcoholic fatty liver disease--A pilot study. Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt B):184-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
16-HETE 関連分類
HY-116444A 関連分類
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