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製品番号: HY-28911

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2-Hydroxyacetaldehyde

2-Hydroxyacetaldehyde acts as a ribonucleotide synthesis precursor and a LDL modifier. 2-Hydroxyacetaldehyde specifically targets lysine residues of high-affinity LDL receptors and their apolipoproteins. By blocking the ε-amino groups of apolipoproteins, 2-Hydroxyacetaldehyde prevents receptor recognition, thereby reducing LDL degradation by macrophages. 2-Hydroxyacetaldehyde generates modified LDL, which serves as a probe for investigating non-receptor-dependent catabolic pathways.

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CAS 番号: 141-46-8
分子式: C₂H₄O₂
分子量:60.05

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-Hydroxyacetaldehyde 構造式

CAS 番号: 141-46-8

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

2-Hydroxyacetaldehyde (80 mM; 2.5-21 h at 37°C) rapidly modifies lysine residues on human LDL^[1].
2-hydroxyacetaldehyde-modified human LDL (100 μg/mL) does not compete with native LDL for LDL receptors on cultured normal human fibroblasts, resulting in a degradation rate of 94% relative to the no-competitor control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 141-46-8
分子量 60.05
分子式 C₂H₄O₂
SMILES

OCC=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Shepherd J, Packard C J. Receptor-independent low-density lipoprotein catabolism[M]//Methods in enzymology. Academic Press, 1986, 129: 566-590.

[2]. Harman CE, et al. Atmospheric production of glycolaldehyde under hazy prebiotic conditions. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 2013 Apr;43(2):77-98. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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