BRD7116
Based on 1 Customer Validation
BRD7116 is a cell-non-autonomous inhibitor of leukemic stem cells (LSCs). BRD7116, without directly contacting LSCs, can inhibit LSCs merely by altering the microenvironment. BRD7116 also has any cell-autonomous effects on LSCs and induces transcriptional changes consistent with myeloid differentiation. BRD7116 can be used for the study of leukemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.89%
- CAS 番号: 329059-55-4
- 分子式: C28H36N2O4S
- 分子量:496.66
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
BRD7116 (0.0625-16 μM) shows activity against LSCes (the LSC-enriched fraction of cells) (EC50 = 200 nM) and patient-derived, primary human leukemia cells, and displays limited activity against normal hematopoietic stem and progenitor cells (HSPCs) and AML cell lines[1].
BRD7116 (0-15 μM, 3 d) pretreatment of the stroma preferentially inhibits the LSCe cells compared to HSPCs[1].
BRD7116 (5 μM, 6 h) induced transcriptional changes consistent with myeloid differentiation in LSCes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 329059-55-4
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性状 Solid
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分子量 496.66
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分子式 C28H36N2O4S
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Color White to off-white
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SMILES
O=S(C1=CC=C(NC(C2C(C)(C)C2(C)C)=O)C=C1)(C3=CC=C(NC(C4C(C)(C)C4(C)C)=O)C=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
体外:
DMSO : ≥ 48 mg/mL (96.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0134 mL | 10.0672 mL | 20.1345 mL | 50.3362 mL |
| 5 mM | 0.4027 mL | 2.0134 mL | 4.0269 mL | 10.0672 mL | |
| 10 mM | 0.2013 mL | 1.0067 mL | 2.0134 mL | 5.0336 mL | |
| 15 mM | 0.1342 mL | 0.6711 mL | 1.3423 mL | 3.3557 mL | |
| 20 mM | 0.1007 mL | 0.5034 mL | 1.0067 mL | 2.5168 mL | |
| 25 mM | 0.0805 mL | 0.4027 mL | 0.8054 mL | 2.0134 mL | |
| 30 mM | 0.0671 mL | 0.3356 mL | 0.6711 mL | 1.6779 mL | |
| 40 mM | 0.0503 mL | 0.2517 mL | 0.5034 mL | 1.2584 mL | |
| 50 mM | 0.0403 mL | 0.2013 mL | 0.4027 mL | 1.0067 mL | |
| 60 mM | 0.0336 mL | 0.1678 mL | 0.3356 mL | 0.8389 mL | |
| 80 mM | 0.0252 mL | 0.1258 mL | 0.2517 mL | 0.6292 mL |
BRD7116 関連分類
HY-18714 関連分類
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