Complanatoside A
Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.
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- CAS 番号: 146501-37-3
- 分子式: C27H30O18
- 分子量:642.52
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
A simple and sensitive LC-MS/MS method is developed for the determination of complanatoside A in rat plasma over the range of 2.3–575 ng/mL. Complanatoside A is extracted from plasma by a protein precipitation procedure, separated by LC and detected by MS/MS in positive electrospray ionization mode. The lower limit of quantification is established at 2.3 ng/mL. Intra- and inter-day precisions (LLOQ, low-QC, med-QC and high-QC) are less than 7.9%, and accuracies are between 94.0 and 105.1%. Matrix effect is acceptable (97.9–103.0%) and extraction recovery is reproducible (88.5–94.4%). Complanatoside A is stable in the investigated conditions. The method is applied to the pharmacokinetics of complanatoside A in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 146501-37-3
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分子量 642.52
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分子式 C27H30O18
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SMILES
O=C1C(O[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)=C(C3=CC(O)=C(O[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO)C(O)=C3)OC5=CC(O)=CC(O)=C15
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
DMSO : ≥ 35.7 mg/mL (55.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
Rats: The rats are fasted for 12 h before the experiment. Complanatoside A is formulated in water and a single dose of 30 mg/kg is administered by oral gavage. Blood samples are obtained from the vena orbitalis just prior to dose and at 0.083, 0.167, 0.25, 0.5, 0.75, 1, 2, 3, 5, 7, 10 and 14 h after administration. After centrifugation at 6000g for 10 min, the upper plasma is collected and stored at–20°C before analysis. The data are calculated by Drug&Statistics software[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
参考文献
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5564 mL | 7.7819 mL | 15.5637 mL | 38.9093 mL |
| 5 mM | 0.3113 mL | 1.5564 mL | 3.1127 mL | 7.7819 mL | |
| 10 mM | 0.1556 mL | 0.7782 mL | 1.5564 mL | 3.8909 mL | |
| 15 mM | 0.1038 mL | 0.5188 mL | 1.0376 mL | 2.5940 mL | |
| 20 mM | 0.0778 mL | 0.3891 mL | 0.7782 mL | 1.9455 mL | |
| 25 mM | 0.0623 mL | 0.3113 mL | 0.6225 mL | 1.5564 mL | |
| 30 mM | 0.0519 mL | 0.2594 mL | 0.5188 mL | 1.2970 mL | |
| 40 mM | 0.0389 mL | 0.1945 mL | 0.3891 mL | 0.9727 mL | |
| 50 mM | 0.0311 mL | 0.1556 mL | 0.3113 mL | 0.7782 mL |
Complanatoside A 関連分類
HY-N0624 関連分類
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