製品番号: HY-100395

Copy Link Print Information

F16

カスタマーレビュー

Based on 1 Customer Validation

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.94%
CAS 番号: 36098-33-6
分子式: C₁₆H₁₅IN₂
分子量:362.21

保管条件:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

F16 構造式

CAS 番号: 36098-33-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 臨床実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines. F16 is a mitochondriotoxic compound, and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: F16	Cytotoxicity against human A549 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]
A549	IC₅₀	>60 μM Compound: F16	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38086195]
BEAS-2B	IC₅₀	>100 μM Compound: F16	Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]
HepG2	IC₅₀	>60 μM Compound: F16	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38086195]
L02	IC₅₀	>60 μM Compound: F16	Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38086195]
MCF7	IC₅₀	>100 μM Compound: F16	Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]
NCI-H1975	IC₅₀	>50 μM Compound: F16	Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]
NCI-H446	IC₅₀	>60 μM Compound: F16	Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38086195]
NCI-H460	IC₅₀	>50 μM Compound: F16	Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]

体外実験

F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines^[1].
F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG
Concentration:

3 μM
Incubation Time:

3 days/7 days
Result:

Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras-transgenic mice was not affected.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 36098-33-6
性状 Solid
分子量 362.21
分子式 C₁₆H₁₅IN₂
Color Yellow to orange
SMILES

C[N+]1=CC=C(/C=C/C2=CNC3=C2C=CC=C3)C=C1.[I-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : ≥ 31 mg/mL (85.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 1 mg/mL (2.76 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7608 mL

13.8041 mL

27.6083 mL

5 mM

0.5522 mL

2.7608 mL

5.5217 mL

10 mM

0.2761 mL

1.3804 mL

2.7608 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (285 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42. [Content Brief]

[2]. Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	2.7608 mL	13.8041 mL	27.6083 mL	69.0207 mL
DMSO	5 mM	0.5522 mL	2.7608 mL	5.5217 mL	13.8041 mL
	10 mM	0.2761 mL	1.3804 mL	2.7608 mL	6.9021 mL
	15 mM	0.1841 mL	0.9203 mL	1.8406 mL	4.6014 mL
	20 mM	0.1380 mL	0.6902 mL	1.3804 mL	3.4510 mL
	25 mM	0.1104 mL	0.5522 mL	1.1043 mL	2.7608 mL
	30 mM	0.0920 mL	0.4601 mL	0.9203 mL	2.3007 mL
	40 mM	0.0690 mL	0.3451 mL	0.6902 mL	1.7255 mL
	50 mM	0.0552 mL	0.2761 mL	0.5522 mL	1.3804 mL
	60 mM	0.0460 mL	0.2301 mL	0.4601 mL	1.1503 mL
	80 mM	0.0345 mL	0.1726 mL	0.3451 mL	0.8628 mL

Keywords

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

F16

Anti-Breast Cancer Compound Library

Targeted Diversity Library

Heterocyclic Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

F16

Anti-Breast Cancer Compound Library

Targeted Diversity Library

Heterocyclic Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

F16 関連分類

HY-100395 関連分類