FR167344 free base
FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist. FR167344 free base shows a high affinity binding to the B2 receptor with an IC50 value of 65 nM and no binding affinity for the B1 receptor.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 215258-13-2
- 分子式: C30H28BrCl2N5O4
- 分子量:673.38
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-17446
IcatibantBradykinin Receptor Antagonist -
HY-15039
SSR240612 -
HY-15043
ELN-441958Bradykinin B1 Receptor Antagonist -
HY-17446R
Icatibant (Standard)Bradykinin Receptor Antagonist -
HY-103290
R715Bradykinin B1 Receptor Antagonist -
HY-121156A
Anatibant hydrochlorideBradykinin B2 Receptor Antagonist -
HY-147273
FulimetibantBradykinin Receptor Antagonist -
![Sar-[D-Phe8]-des-Arg9-Bradykinin](https://file.medchemexpress.com/product_pic/hy-103291.gif)
HY-103291
Sar-[D-Phe8]-des-Arg9-BradykininB1 Receptor Agonist -
HY-103289
MEN 11270B2 Kinin Receptor Antagonist -
HY-103293
Lys-BradykininKallidin -
![Lys-[Des-Arg9]Bradykinin](https://file.medchemexpress.com/product_pic/hy-103295.gif)
HY-103295
Lys-[Des-Arg9]BradykininBradykinin B1 Receptor Agonist -
HY-103296
Bombinakinin MBradykinin Receptor Agonist
Bradykinin Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
|
Bradykinin B2 Receptor (B2R) |
体外実験
In competitive experiments using membranes prepared from Chinese hamster ovary cells expressing the bradykinin receptor subtypes, FR167344 shows a high affinity binding to the B2 receptor with IC50 values of 65 nM, and no binding affinity for the B1 receptor. FR167344 inhibits the B2 receptor-mediated phosphatidylinositol (PI) hydrolysis and produces a concentration-dependent rightward shift in the dose-response curve to bradykinin. This shift is accompanied by a progressive reduction of maximal response. Estimated pA2 values for the antagonism of bradykinin induced PI hydrolysis by FR167344 is 8.0. FR167344 shows no stimulatory effects on PI hydrolysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 215258-13-2
-
分子量 673.38
-
分子式 C30H28BrCl2N5O4
-
SMILES
O=C(N(C)C)C1=CC=C(/C=C/C(NCC(N(C2=CC=C(Cl)C(COC3=CC=CN4C3=NC(C)=C4Br)=C2Cl)C)=O)=O)C=C1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Aramori I, et al. Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657. Mol Pharmacol. 1997 Feb;51(2):171-6. [Content Brief]
[2]. Asano M, et al. Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on different in vivoanimal models of inflammation.Br J Pharmacol. 1997 Dec;122(7):1436-40. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FR167344 free base 関連分類
HY-100301 関連分類
Powered by Bioz