Hesperin
Based on 1 Customer Validation
Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.20%
- CAS 番号: 4430-35-7
- 分子式: C8H15NOS2
- 分子量:205.34
-
保管条件:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-112675
4-Octyl itaconateNrf2 Activator -
HY-101140
KI696KEAP1/NRF2 Protein-protein Interaction Inhibitor -
HY-19734
NK-252Nrf2 Activator -
HY-100523
ML385Nrf2 Inhibitor -
HY-12212
OmaveloxoloneNrf2 Activator -
HY-101025
Nrf2-IN-1Nrf2 Inhibitor -
HY-19543
BrusatolNrf2 Inhibitor -
HY-17363
Dimethyl fumarateNrf2 Activator -
HY-12213
CDDO-EAKeap1-Nrf2 Activator -
HY-12519
OltiprazHIF-1α Inhibitor -
HY-14909
BardoxoloneNrf2 Activator -
HY-N0606
Ginsenoside Rh3Nrf2 Activator
生物活性
製品説明
IC50 & Target
Nrf2[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| J774.1 | IC50 |
5.7 μM
Compound: 6-MITC
|
Antiinflammatory activity in mouse J774.1 cells assessed as inhibition of IFN-gamma and LPS-induced nitric oxide production after 20 to 24 hrs by Griess assay
Antiinflammatory activity in mouse J774.1 cells assessed as inhibition of IFN-gamma and LPS-induced nitric oxide production after 20 to 24 hrs by Griess assay
|
[PMID: 19716210] |
| J774.1 | IC50 |
8 μM
Compound: 6-MITC
|
Growth inhibition of mouse J774.1 cells assessed as cell viability after 24 hrs by MTT assay
Growth inhibition of mouse J774.1 cells assessed as cell viability after 24 hrs by MTT assay
|
[PMID: 19716210] |
体外実験
Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) is an active compound in wasabi (Wasabia japonica Matsum.). Whether Hesperin induces cytotoxicity of HUVECs is determined. More than 1 μg/mL of Hesperin markedly induces cytotoxicity and morphological alterations. In subsequent experiments we used Hesperin is used at concentrations of 0-1 μg/mL, to study the anti-coagulant and anti-inflammatory properties of Hesperin in HUVECs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 4430-35-7
-
性状 Liquid
-
分子量 205.34
-
分子式 C8H15NOS2
-
Color Colorless to light yellow
-
SMILES
O=S(CCCCCCN=C=S)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Solution, -20°C, 2 years
純度とドキュメンテーション
-
データシート (269 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Tanaka Y, et al. 6-Methylsulfinylhexyl isothiocyanate prevents high-fat diet-induced fatty liver but fails to attenuate hepatic iron accumulation in mice. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1153-1156. [Content Brief]
[2]. Okamoto T, et al. 6-Methylsulfinylhexyl isothiocyanate modulates endothelial cell function and suppresses leukocyte adhesion. J Nat Med. 2014 Jan;68(1):144-53. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Hesperin 関連分類
HY-101371 関連分類
Powered by Bioz