Myomodulin
Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.
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- CAS 番号: 110570-93-9
- 分子式: C36H67N11O8S2
- 分子量:846.12
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Myomodulin decreases period and increases spike frequency in oscillator heart interneurons. Myomodulin enhances the hyperpolarization-activated cation current and inhibits the electrogenic Na/K pump[1]. A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis. The peptide evokes a membrane outward current (EC50 approximately 2 μM), which neither desensitizes nor shows any sign of run-down, and elicits a K+ conductance increase of the glial cell membrane[2]. Myomodulin modulate ion channels in a wide variety of organisms including Aplysia, Lymnaea, and Pleurobranchaea. Myomodulin differentially modulates the potassium currents and reduces the amplitude of the Ca2+ current by 20%[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 110570-93-9
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分子量 846.12
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分子式 C36H67N11O8S2
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配列
Pro-Met-Ser-Met-Leu-Arg-Leu-NH2
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シーケンスの短縮
PMSMLRL-NH2
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Structure Classification
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Initial Source
molluscs, insects, and gastropods
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tobin AE, et al. Myomodulin increases Ih and inhibits the NA/K pump to modulate bursting in leech heart interneurons. J Neurophysiol. 2005 Dec;94(6):3938-50. [Content Brief]
[2]. Britz FC, et al. Membrane responses of the leech giant glial cell to the peptide transmitter myomodulin. Peptides. 2002 Dec;23(12):2117-25. [Content Brief]
[3]. Wang Y, et al. Modulatory effects of myomodulin on the excitability and membrane currents in Retzius cells of the leech. J Neurophysiol. 1999 Jul;82(1):216-25. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Myomodulin 関連分類
HY-P0268 関連分類
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