PSB-12379
Based on 5 publication(s) in Google Scholar
PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).
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- 純度: 99.96%
- CAS 番号: 1802226-78-3
- 分子式: C18H23N5O9P2
- 分子量:515.35
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 PSB-12379
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生物活性
Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)[1]
Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1802226-78-3
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性状 Solid
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分子量 515.35
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分子式 C18H23N5O9P2
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Color White to off-white
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SMILES
O=P(O)(O)CP(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)[C@H](O)[C@@H]1O)(O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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Front Bioeng Biotechnol
CD73-Positive Small Extracellular Vesicles Derived From Umbilical Cord Mesenchymal Stem Cells Promote the Proliferation and Migration of Pediatric Urethral Smooth Muscle Cells Through Adenosine Pathway. [Abstract]2022 Apr 27;10:895998. PMID: 35573239 -
Cancers (Basel)
Adenosine 2A Receptor Activation Amplifies Ibrutinib Antiplatelet Effect; Implications in Chronic Lymphocytic Leukemia. [Abstract]2022 Nov 23;14(23):5750. PMID: 36497231 -
bioRxiv
Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation. [Abstract]2026 Apr 1:2026.03.31.715684. PMID: 41959015 -
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溶剤 & 溶解度
H2O : 125 mg/mL (242.55 mM; Need ultrasonic)
DMSO : ≥ 5 mg/mL (9.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (194.04 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (281 KB)
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SDS (583 KB)
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- Portuguese - PT (583 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.9404 mL | 9.7021 mL | 19.4043 mL | 48.5107 mL |
| 5 mM | 0.3881 mL | 1.9404 mL | 3.8809 mL | 9.7021 mL | |
| H2O | 10 mM | 0.1940 mL | 0.9702 mL | 1.9404 mL | 4.8511 mL |
| 15 mM | 0.1294 mL | 0.6468 mL | 1.2936 mL | 3.2340 mL | |
| 20 mM | 0.0970 mL | 0.4851 mL | 0.9702 mL | 2.4255 mL | |
| 25 mM | 0.0776 mL | 0.3881 mL | 0.7762 mL | 1.9404 mL | |
| 30 mM | 0.0647 mL | 0.3234 mL | 0.6468 mL | 1.6170 mL | |
| 40 mM | 0.0485 mL | 0.2426 mL | 0.4851 mL | 1.2128 mL | |
| 50 mM | 0.0388 mL | 0.1940 mL | 0.3881 mL | 0.9702 mL | |
| 60 mM | 0.0323 mL | 0.1617 mL | 0.3234 mL | 0.8085 mL | |
| 80 mM | 0.0243 mL | 0.1213 mL | 0.2426 mL | 0.6064 mL | |
| 100 mM | 0.0194 mL | 0.0970 mL | 0.1940 mL | 0.4851 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PSB-12379 関連分類
HY-100747 関連分類
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