Sodium Channel Control

(R)-Eslicarbazepine acetate (BIA 2-059) is the R-enantiomer of Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate is an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

(Rac)-Atomoxetine hydrochloride ((Rac)-Tomoxetine (hydrochloride); (Rac)-LY 139603) is the racemic mixture of Atomoxetine hydrochloride (HY-17385). Atomoxetine hydrochloride is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine hydrochloride is a potent Na⁺ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.

N-Hydroxy riluzole is a metabolite of the antiglutamatergic agent Riluzole (HY-B0211).

Anticonvulsant agent 7 is an orally active, broad-spectrum anticonvulsant that does not rely on direct blockade of Na⁺/Ca²⁺ channels. Anticonvulsant agent 7 can be used in seizure research^[1].

Lamotrigine N2-Oxide is a metabolite of the anticonvulsant Lamotrigine (HY-B0495).