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製品番号: HY-114674

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A-127722

A-127722 is A 2, 4-dialarylpyrrolidine-3-carboxylic acid ET_A selective endothelin receptor (ET receptor) antagonist with IC₅₀ value of 0.36 nM.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 195704-72-4
分子式: C₂₉H₃₈N₂O₆
分子量:510.62

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

A-127722 構造式

CAS 番号: 195704-72-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

A-127722 is A 2, 4-dialarylpyrrolidine-3-carboxylic acid ET_A selective endothelin receptor (ET receptor) antagonist with IC₅₀ value of 0.36 nM^[1].

Endothelin Receptor アイソフォーム固有の製品をすべて表示 :

ET_A
ET_B

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.055 nM Compound: 5; ABT-627; Xinlay	Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane	[PMID: 27266371]
MMQ	IC₅₀	0.04 nM Compound: 17v	Inhibition of phosphoinositol hydrolysis of MMQ cells. Inhibition of phosphoinositol hydrolysis of MMQ cells.	[PMID: 8676339]
MMQ	IC₅₀	0.31 nM Compound: 17v	Inhibitory activity against the Endothelin A receptor of rat MMQ cells Inhibitory activity against the Endothelin A receptor of rat MMQ cells	[PMID: 8676339]
MMQ	IC₅₀	0.36 nM Compound: 1	Binding affinity against Endothelin A receptor in MMQ cells in rat Binding affinity against Endothelin A receptor in MMQ cells in rat	[PMID: 11689084]
Pituitary gland cell	IC₅₀	0.4 nM Compound: 13	Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand. Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.	[PMID: 9022798]

化学情報

CAS 番号 195704-72-4
分子量 510.62
分子式 C₂₉H₃₈N₂O₆
SMILES

O=C([C@H]1[C@H](C2=CC=C(OC)C=C2)N(CC(N(CCCC)CCCC)=O)C[C@@H]1C3=CC=C(OCO4)C4=C3)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Winn M, et al. 2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722. J Med Chem. 1996 Mar 1;39(5):1039-48. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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