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United States

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製品番号: HY-185984

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a12k4E-Ca

a12k4E-Ca is a C-terminal glutamate-modified peptidogenic ionizable lipid that can be used for the preparation of lipid nanoparticles (LNPs). a12k4E-Ca preferentially accumulates in the spleen in vivo, acts as a carrier to mediate spleen-selective mRNA delivery, and enables spleen-specific Cre recombinase-mediated gene editing. a12k4E-Ca restores serum biochemical parameters and cytokines/chemokines. a12k4E-Ca can be used in studies related to LNP preparation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₂₇H₂₅₁N₉O₉
分子量:2048.41

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

a12k4E-Ca 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

a12K4E-Ca LNPs (0.3 mg/kg; intravenous injection; single administration) enable spleen-selective mRNA delivery in healthy female C57BL/6 mice, with organ specificity reaching 91.8%-95.2%^[1].
a12K4E-Ca LNPs (intravenous injection; single dose) preferentially accumulate in the spleen following intravenous administration in healthy female C57BL/6 mice; moreover, they mediate spleen-specific Cre-based gene editing in Ai9 reporter mice, with tdTomato expression levels 3.7-fold higher than those of the control group^[1].
a12K4E-Ca LNPs (4 mg/kg; intravenous injection; single administration) induced transient and recoverable alterations in serum biochemical indicators as well as cytokine and chemokine levels of healthy female C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 2048.41
分子式 C₁₂₇H₂₅₁N₉O₉
SMILES

CCCCCCCCCCCCN(CCCC[C@H](NC(C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)CCCCCCCCCCCC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Lin Y, et al. Tissue-specific mRNA delivery and prime editing with peptide-ionizable lipid nanoparticles. Nature materials. 2026 Jan;25(1):133-145. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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