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United States

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製品番号: HY-P991993

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AB054

AB054 is a humanized monoclonal antibody targeting factor XII (FXII). AB054 inhibits FXII activation and FXIIa activity through specific binding to the catalytic domain of FXII, and exerts antithrombotic effects in a concentration-dependent manner. AB054 can be used in studies related to thrombosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AB054 構造式

容量

価格（税別）

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数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Species Reactivity
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Target
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Species Reactivity

Human

体外実験

AB054 (0-100 μg/mL; 5 min) significantly prolongs the aPTT of human plasma and baboon plasma in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

AB054 (2-5 mg/kg; i.v. bolus; 30 min before experiment) significantly inhibits platelet-dependent thrombosis in baboon membrane oxygenators, and its antithrombotic effect becomes more pronounced when used in combination with Heparin (HY-17567)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Baboons (juvenile male, 9~15kg, with healed surgically implanted chronic arteriovenous shunt device)^[1]
Dosage:

5 mg/kg (single agent); 2 mg/kg (plus 5 mg/kg 24h prior, in combination with 20 U/kg heparin)
Administration:

i.v. bolus; 30 min before experiment (AB054); 15 min before experiment (heparin)
Result:

Reduced platelet deposition rate, terminal platelet deposition, and terminal fibrin content in.
Maintained hemostatic parameters (bleeding time, blood loss, bleeding rate) within normal baboon ranges across all treatment groups.

遺伝子ID

2161 [NCBI]

アクセッション番号

P00748

Target

F12/Factor XII

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

アプリケーション

ELISA, FACS, Functional assay

化学情報

SMILES

[AB054]
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Andras Gruber, et al. Therapeutic factor xii antibody. HK40062102A. 2022-06-10.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- Species Reactivity
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Target
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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製品名:
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AB054

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

AB054 関連分類

HY-P991993 関連分類